scf ubiquitin ligase complex Gene Set
Dataset
GO Cellular Component Annotations 2015
Category
structural or functional annotations
Type
cellular component
Description
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). (Gene Ontology , GO_0019005 )
External Link
http://amigo.geneontology.org/amigo/term/GO:0019005
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Genes
30 proteins localized to the scf ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.
Symbol
Name
BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase
CCNF
cyclin F
CUL1
cullin 1
FBXL15
F-box and leucine-rich repeat protein 15
FBXL19
F-box and leucine-rich repeat protein 19
FBXL2
F-box and leucine-rich repeat protein 2
FBXL21
F-box and leucine-rich repeat protein 21 (gene/pseudogene)
FBXL3
F-box and leucine-rich repeat protein 3
FBXL5
F-box and leucine-rich repeat protein 5
FBXL7
F-box and leucine-rich repeat protein 7
FBXO15
F-box protein 15
FBXO17
F-box protein 17
FBXO2
F-box protein 2
FBXO25
F-box protein 25
FBXO27
F-box protein 27
FBXO31
F-box protein 31
FBXO4
F-box protein 4
FBXO44
F-box protein 44
FBXO6
F-box protein 6
FBXO9
F-box protein 9
FBXW11
F-box and WD repeat domain containing 11
FBXW5
F-box and WD repeat domain containing 5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FBXW8
F-box and WD repeat domain containing 8
PARK2
parkin RBR E3 ubiquitin protein ligase
RBX1
ring-box 1, E3 ubiquitin protein ligase
SKP1
S-phase kinase-associated protein 1
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TRIM21
tripartite motif containing 21
USP47
ubiquitin specific peptidase 47