| Dataset | GeneRIF Biological Term Annotations |
| Category | structural or functional annotations |
| Type | biological term |
| Description | A tumor of the peripheral nervous system composed of neoplastic Schwann cells. The vast majority of schwannomas follow a benign clinical course. Only rare cases associated with a malignant clinical course have been reported.|A benign, usually encapsulated slow growing tumor of the peripheral nervous system composed of well differentiated Schwann cells. It recurs infrequently and only rare cases associated with malignant transformation have been reported.|A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)|A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance (MeSH). (Experimental Factor Ontology, EFO_0000693) |
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39 genes co-occuring with the biological term schwannoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
| Symbol | Name |
|---|---|
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 |
| AXL | AXL receptor tyrosine kinase |
| BDNF | brain-derived neurotrophic factor |
| BMP2 | bone morphogenetic protein 2 |
| BMP3 | bone morphogenetic protein 3 |
| BMP4 | bone morphogenetic protein 4 |
| BMP5 | bone morphogenetic protein 5 |
| CALB2 | calbindin 2 |
| CCND1 | cyclin D1 |
| CD34 | CD34 molecule |
| CD44 | CD44 molecule (Indian blood group) |
| CLDN1 | claudin 1 |
| EGFR | epidermal growth factor receptor |
| ESR1 | estrogen receptor 1 |
| EZR | ezrin |
| GAS6 | growth arrest-specific 6 |
| GFAP | glial fibrillary acidic protein |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate |
| IGFBP1 | insulin-like growth factor binding protein 1 |
| IL17A | interleukin 17A |
| JUN | jun proto-oncogene |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha |
| MAPK8 | mitogen-activated protein kinase 8 |
| MIR21 | microRNA 21 |
| NF2 | neurofibromin 2 (merlin) |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide |
| PTEN | phosphatase and tensin homolog |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
| RELA | v-rel avian reticuloendotheliosis viral oncogene homolog A |
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 |
| SOX10 | SRY (sex determining region Y)-box 10 |
| SOX2 | SRY (sex determining region Y)-box 2 |
| SPP1 | secreted phosphoprotein 1 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) |
| THBD | thrombomodulin |
| WT1 | Wilms tumor 1 |
