sclera Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The tough white outer coat of the eyeball, covering approximately the posterior five-sixths of its surface, and continuous anteriorly with the cornea and posteriorly with the external sheath of the optic nerve. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001606)
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Genes

274 proteins co-occuring with the tissue sclera in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
HGD homogentisate 1,2-dioxygenase 1.79144
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 1.68404
LUM lumican 1.48364
DCN decorin 1.43848
COL1A1 collagen, type I, alpha 1 1.42183
ADAL adenosine deaminase-like 1.39009
MMP2 matrix metallopeptidase 2 1.31153
FMOD fibromodulin 1.29534
TMEM98 transmembrane protein 98 1.27471
ACAN aggrecan 1.24922
MTERF3 mitochondrial transcription termination factor 3 1.23272
DPT dermatopontin 1.22069
PRIMPOL primase and polymerase (DNA-directed) 1.17181
UROS uroporphyrinogen III synthase 1.16781
COL1A2 collagen, type I, alpha 2 1.07971
ZNF469 zinc finger protein 469 1.07927
RHO rhodopsin 1.07706
FN1 fibronectin 1 1.06206
PRELP proline/arginine-rich end leucine-rich repeat protein 1.04269
BGN biglycan 1.00196
LECT1 leukocyte cell derived chemotaxin 1 0.961607
TGFB2 transforming growth factor, beta 2 0.943075
ZC3H11A zinc finger CCCH-type containing 11A 0.937917
ALB albumin 0.931479
VCAN versican 0.929764
KERA keratocan 0.926336
LAX1 lymphocyte transmembrane adaptor 1 0.925907
TNC tenascin C 0.923339
CRTAP cartilage associated protein 0.923339
MMP1 matrix metallopeptidase 1 0.921199
TIMP2 TIMP metallopeptidase inhibitor 2 0.896895
CHRM5 cholinergic receptor, muscarinic 5 0.891374
EPYC epiphycan 0.889678
TIMP1 TIMP metallopeptidase inhibitor 1 0.887133
OPTC opticin 0.877397
ADAMTSL4 ADAMTS-like 4 0.874439
MMP3 matrix metallopeptidase 3 0.863048
SLC22A18 solute carrier family 22, member 18 0.863048
MPZ myelin protein zero 0.847484
LMLN leishmanolysin-like (metallopeptidase M8 family) 0.808551
VEGFA vascular endothelial growth factor A 0.801876
P3H1 prolyl 3-hydroxylase 1 0.801042
IFITM2 interferon induced transmembrane protein 2 0.800626
ASB14 ankyrin repeat and SOCS box containing 14 0.781894
BCAN brevican 0.759086
ALPPL2 alkaline phosphatase, placental-like 2 0.75495
ALPL alkaline phosphatase, liver/bone/kidney 0.754124
ALPP alkaline phosphatase, placental 0.753297
EYA2 EYA transcriptional coactivator and phosphatase 2 0.747927
OLFM3 olfactomedin 3 0.735971
TGFB1 transforming growth factor, beta 1 0.733089
OGN osteoglycin 0.728152
PLAT plasminogen activator, tissue 0.718292
HAPLN4 hyaluronan and proteoglycan link protein 4 0.711319
PPCDC phosphopantothenoylcysteine decarboxylase 0.71009
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.704355
FGF2 fibroblast growth factor 2 (basic) 0.693719
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 0.692493
PAX6 paired box 6 0.690042
MATK megakaryocyte-associated tyrosine kinase 0.688409
TGFBI transforming growth factor, beta-induced, 68kDa 0.686776
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.674543
FKBP10 FK506 binding protein 10, 65 kDa 0.668029
CHRM4 cholinergic receptor, muscarinic 4 0.664368
PRDM5 PR domain containing 5 0.640023
LYPLAL1 lysophospholipase-like 1 0.638809
PEX19 peroxisomal biogenesis factor 19 0.637999
TH tyrosine hydroxylase 0.63274
TCTA T-cell leukemia translocation altered 0.622639
TMC8 transmembrane channel-like 8 0.617393
WDR36 WD repeat domain 36 0.614571
HAPLN1 hyaluronan and proteoglycan link protein 1 0.608527
ENO2 enolase 2 (gamma, neuronal) 0.608124
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 0.606916
LDB2 LIM domain binding 2 0.604502
SLC39A5 solute carrier family 39 (zinc transporter), member 5 0.600077
IGF1 insulin-like growth factor 1 (somatomedin C) 0.598067
STK38 serine/threonine kinase 38 0.590839
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.590036
C1ORF167 chromosome 1 open reading frame 167 0.588832
MMP9 matrix metallopeptidase 9 0.588832
TIMP3 TIMP metallopeptidase inhibitor 3 0.58282
VGLL3 vestigial-like family member 3 0.577215
JMJD6 jumonji domain containing 6 0.576816
PRTN3 proteinase 3 0.576015
TRAPPC10 trafficking protein particle complex 10 0.575616
ADORA2B adenosine A2b receptor 0.566828
BMP2 bone morphogenetic protein 2 0.561644
SP6 Sp6 transcription factor 0.56005
PITX2 paired-like homeodomain 2 0.56005
PDPN podoplanin 0.558457
F2 coagulation factor II (thrombin) 0.557661
CHRM1 cholinergic receptor, muscarinic 1 0.556467
OLFML3 olfactomedin-like 3 0.555274
VSX1 visual system homeobox 1 0.551695
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.551298
LAMA3 laminin, alpha 3 0.530298
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.529113
EYA3 EYA transcriptional coactivator and phosphatase 3 0.526744
GLB1 galactosidase, beta 1 0.517284
HSPG2 heparan sulfate proteoglycan 2 0.517284
ZNF699 zinc finger protein 699 0.51453
MAF1 MAF1 homolog (S. cerevisiae) 0.509813
KIAA0586 KIAA0586 0.505887
LOXL3 lysyl oxidase-like 3 0.503141
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.503141
MIR98 microRNA 98 0.501182
RPE65 retinal pigment epithelium-specific protein 65kDa 0.499223
AQP12A aquaporin 12A 0.497657
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.497266
VIP vasoactive intestinal peptide 0.496483
PTGFR prostaglandin F receptor (FP) 0.494918
FBLN1 fibulin 1 0.4914
MATN1 matrilin 1, cartilage matrix protein 0.489057
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.484376
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.468048
CHRM3 cholinergic receptor, muscarinic 3 0.46766
MSTO1 misato 1, mitochondrial distribution and morphology regulator 0.464561
PRCD progressive rod-cone degeneration 0.461078
TAC1 tachykinin, precursor 1 0.459532
AXL AXL receptor tyrosine kinase 0.459532
SCPEP1 serine carboxypeptidase 1 0.456055
MIRLET7E microRNA let-7e 0.451042
SYP synaptophysin 0.448346
BIN3 bridging integrator 3 0.440658
PRB3 proline-rich protein BstNI subfamily 3 0.439507
CA2 carbonic anhydrase II 0.43414
CMA1 chymase 1, mast cell 0.427254
FBXO7 F-box protein 7 0.424963
CPSF3L cleavage and polyadenylation specific factor 3-like 0.424199
ADORA2A adenosine A2a receptor 0.420385
CALB1 calbindin 1, 28kDa 0.419242
MUT methylmalonyl CoA mutase 0.417337
ANGPTL7 angiopoietin-like 7 0.416576
CHMP2B charged multivesicular body protein 2B 0.415053
FGFR1 fibroblast growth factor receptor 1 0.411251
PEX10 peroxisomal biogenesis factor 10 0.408972
SIX2 SIX homeobox 2 0.405176
TRIM37 tripartite motif containing 37 0.404797
NYX nyctalopin 0.404039
DDT D-dopachrome tautomerase 0.40366
BMP3 bone morphogenetic protein 3 0.402901
LPIN2 lipin 2 0.40025
BEST1 bestrophin 1 0.396087
AQP11 aquaporin 11 0.395709
CRYAA crystallin, alpha A 0.392686
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.390799
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.386273
TCERG1 transcription elongation regulator 1 0.383637
LACTB lactamase, beta 0.382884
ANKH ANKH inorganic pyrophosphate transport regulator 0.381003
NCAN neurocan 0.379875
COL2A1 collagen, type II, alpha 1 0.379875
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.379123
AQP10 aquaporin 10 0.378372
BAG6 BCL2-associated athanogene 6 0.374993
MTF1 metal-regulatory transcription factor 1 0.373118
IHH indian hedgehog 0.371245
TUBE1 tubulin, epsilon 1 0.37087
CFH complement factor H 0.370121
DAND5 DAN domain family member 5, BMP antagonist 0.369373
CD44 CD44 molecule (Indian blood group) 0.369373
CTGF connective tissue growth factor 0.368624
MIR107 microRNA 107 0.363393
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.361155
GCGR glucagon receptor 0.360782
NTN4 netrin 4 0.358546
PDLIM1 PDZ and LIM domain 1 0.357802
CRYAB crystallin, alpha B 0.354084
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.352969
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 0.350372
TAS1R1 taste receptor, type 1, member 1 0.348519
ZBTB20 zinc finger and BTB domain containing 20 0.346668
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 0.342971
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.340019
RPTOR regulatory associated protein of MTOR, complex 1 0.338177
MFRP membrane frizzled-related protein 0.337072
STIL SCL/TAL1 interrupting locus 0.336704
RICTOR RPTOR independent companion of MTOR, complex 2 0.332294
IGFBP6 insulin-like growth factor binding protein 6 0.33156
ATN1 atrophin 1 0.331194
CHAD chondroadherin 0.330827
RARB retinoic acid receptor, beta 0.330094
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 0.328994
PCNA proliferating cell nuclear antigen 0.326432
CHRM2 cholinergic receptor, muscarinic 2 0.325335
IRF6 interferon regulatory factor 6 0.323874
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.321685
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.316951
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.316588
ASRGL1 asparaginase like 1 0.31332
PGF placental growth factor 0.310783
NID2 nidogen 2 (osteonidogen) 0.310421
VIPR2 vasoactive intestinal peptide receptor 2 0.309697
MIRLET7C microRNA let-7c 0.309697
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.306805
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.306444
FAIM2 Fas apoptotic inhibitory molecule 2 0.306083
TUFT1 tuftelin 1 0.302838
MCM8 minichromosome maintenance complex component 8 0.301039
CD68 CD68 molecule 0.300679
SLC7A4 solute carrier family 7, member 4 0.298883
TPT1 tumor protein, translationally-controlled 1 0.296372
RCVRN recoverin 0.294223
CLCN7 chloride channel, voltage-sensitive 7 0.293151
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.292436
TBCE tubulin folding cofactor E 0.292079
TSPAN1 tetraspanin 1 0.292079
AQP6 aquaporin 6, kidney specific 0.290295
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.287092
SCO2 SCO2 cytochrome c oxidase assembly protein 0.287092
GIN1 gypsy retrotransposon integrase 1 0.285316
MTNR1A melatonin receptor 1A 0.28107
MIR214 microRNA 214 0.28107
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.28107
B3GAT1 beta-1,3-glucuronyltransferase 1 0.279659
VASH1 vasohibin 1 0.278955
GLS glutaminase 0.278955
MTNR1B melatonin receptor 1B 0.271952
FGF1 fibroblast growth factor 1 (acidic) 0.271604
FLT1 fms-related tyrosine kinase 1 0.270561
EMP2 epithelial membrane protein 2 0.269867
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.268828
TKT transketolase 0.267102
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.266069
PLVAP plasmalemma vesicle associated protein 0.265381
MLANA melan-A 0.262986
TNMD tenomodulin 0.262645
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.260945
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 0.257572
CALD1 caldesmon 1 0.256568
CSHL1 chorionic somatomammotropin hormone-like 1 0.2559
VIT vitrin 0.254902
COL18A1 collagen, type XVIII, alpha 1 0.253908
F3 coagulation factor III (thromboplastin, tissue factor) 0.253578
GJA1 gap junction protein, alpha 1, 43kDa 0.252919
MMP8 matrix metallopeptidase 8 0.25259
TGFBR3 transforming growth factor, beta receptor III 0.25259
CYCS cytochrome c, somatic 0.252261
KIF23 kinesin family member 23 0.249977
FANCB Fanconi anemia, complementation group B 0.248683
RBP1 retinol binding protein 1, cellular 0.24676
TGFB3 transforming growth factor, beta 3 0.246124
RBP3 retinol binding protein 3, interstitial 0.245807
ICAM2 intercellular adhesion molecule 2 0.242672
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.240216
STAP2 signal transducing adaptor family member 2 0.239307
PMM2 phosphomannomutase 2 0.238406
MID2 midline 2 0.23604
ACHE acetylcholinesterase (Yt blood group) 0.235167
GLS2 glutaminase 2 (liver, mitochondrial) 0.233731
FTL ferritin, light polypeptide 0.232599
CLIC1 chloride intracellular channel 1 0.23011
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.229299
PNMA2 paraneoplastic Ma antigen 2 0.228764
FTH1 ferritin, heavy polypeptide 1 0.227445
AQP5 aquaporin 5 0.226926
CELF1 CUGBP, Elav-like family member 1 0.226667
ATAD2 ATPase family, AAA domain containing 2 0.2259
CCM2 cerebral cavernous malformation 2 0.225647
CD22 CD22 molecule 0.224645
BMP8B bone morphogenetic protein 8b 0.224398
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.223906
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 0.222699
THBS1 thrombospondin 1 0.221291
HN1 hematological and neurological expressed 1 0.220831
CDKN2A cyclin-dependent kinase inhibitor 2A 0.220831
COCH cochlin 0.220604
OCRL oculocerebrorenal syndrome of Lowe 0.215928
NOTCH1 notch 1 0.215341
TCEA1 transcription elongation factor A (SII), 1 0.214017
NID1 nidogen 1 0.213833
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.213112
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.212586