scopolamine N-oxide-6335 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the scopolamine N-oxide-6335 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ANKLE2 ankyrin repeat and LEM domain containing 2
APOLD1 apolipoprotein L domain containing 1
ARHGAP24 Rho GTPase activating protein 24
ARHGAP33 Rho GTPase activating protein 33
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BAIAP3 BAI1-associated protein 3
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BTD biotinidase
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CDC25A cell division cycle 25A
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CEP350 centrosomal protein 350kDa
CLCN4 chloride channel, voltage-sensitive 4
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CYBA cytochrome b-245, alpha polypeptide
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCTN1 dynactin 1
DENND3 DENN/MADD domain containing 3
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOCK5 dedicator of cytokinesis 5
DST dystonin
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FAM13A family with sequence similarity 13, member A
FBXO31 F-box protein 31
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FRMPD1 FERM and PDZ domain containing 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GAS8 growth arrest-specific 8
GM2A GM2 ganglioside activator
GPR3 G protein-coupled receptor 3
HIST1H3F histone cluster 1, H3f
HIST1H4B histone cluster 1, H4b
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DOA major histocompatibility complex, class II, DO alpha
ICAM5 intercellular adhesion molecule 5, telencephalin
IGHM immunoglobulin heavy constant mu
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL33 interleukin 33
INO80B INO80 complex subunit B
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KCNIP1 Kv channel interacting protein 1
LAMA4 laminin, alpha 4
LDB3 LIM domain binding 3
LY6G6C lymphocyte antigen 6 complex, locus G6C
MANBA mannosidase, beta A, lysosomal
MARK4 MAP/microtubule affinity-regulating kinase 4
MB myoglobin
MED16 mediator complex subunit 16
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MRPS12 mitochondrial ribosomal protein S12
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MVK mevalonate kinase
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP1 NEDD4 binding protein 1
NEBL nebulette
NOX1 NADPH oxidase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NSD1 nuclear receptor binding SET domain protein 1
NUP214 nucleoporin 214kDa
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAPPA2 pappalysin 2
PARM1 prostate androgen-regulated mucin-like protein 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PKP3 plakophilin 3
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
PPARA peroxisome proliferator-activated receptor alpha
PRKG2 protein kinase, cGMP-dependent, type II
PRSS22 protease, serine, 22
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RGS5 regulator of G-protein signaling 5
RIMS2 regulating synaptic membrane exocytosis 2
RIMS3 regulating synaptic membrane exocytosis 3
SAP30 Sin3A-associated protein, 30kDa
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STBD1 starch binding domain 1
SYNJ2 synaptojanin 2
TENM1 teneurin transmembrane protein 1
TOP3A topoisomerase (DNA) III alpha
TTC38 tetratricopeptide repeat domain 38
UBE3B ubiquitin protein ligase E3B
USB1 U6 snRNA biogenesis 1
WWOX WW domain containing oxidoreductase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF174 zinc finger protein 174

decreased expression

Symbol Name
ABT1 activator of basal transcription 1
ACAD10 acyl-CoA dehydrogenase family, member 10
ACP2 acid phosphatase 2, lysosomal
ADCY7 adenylate cyclase 7
ADGRF1 adhesion G protein-coupled receptor F1
ALS2CL ALS2 C-terminal like
APH1B APH1B gamma secretase subunit
ASB13 ankyrin repeat and SOCS box containing 13
ATP13A2 ATPase type 13A2
C11ORF63 chromosome 11 open reading frame 63
CCDC106 coiled-coil domain containing 106
CCDC85C coiled-coil domain containing 85C
CEP131 centrosomal protein 131kDa
CHKB choline kinase beta
CHPF chondroitin polymerizing factor
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLDN11 claudin 11
CLEC2B C-type lectin domain family 2, member B
CORO2A coronin, actin binding protein, 2A
CORT cortistatin
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ERF Ets2 repressor factor
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM131A family with sequence similarity 131, member A
FGF13 fibroblast growth factor 13
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GRWD1 glutamate-rich WD repeat containing 1
HHLA3 HERV-H LTR-associating 3
HIRA histone cell cycle regulator
HOXA2 homeobox A2
HOXA4 homeobox A4
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL11RA interleukin 11 receptor, alpha
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
LHFPL2 lipoma HMGIC fusion partner-like 2
LRP3 low density lipoprotein receptor-related protein 3
LRP5L low density lipoprotein receptor-related protein 5-like
LZTR1 leucine-zipper-like transcription regulator 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MOXD1 monooxygenase, DBH-like 1
MRPL41 mitochondrial ribosomal protein L41
MRPS34 mitochondrial ribosomal protein S34
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NECAP2 NECAP endocytosis associated 2
NLRX1 NLR family member X1
NRTN neurturin
PACS1 phosphofurin acidic cluster sorting protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POMT2 protein-O-mannosyltransferase 2
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PRPH peripherin
PSKH1 protein serine kinase H1
PYCARD PYD and CARD domain containing
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB4B RAB4B, member RAS oncogene family
RPAP1 RNA polymerase II associated protein 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SECTM1 secreted and transmembrane 1
SH2D4A SH2 domain containing 4A
SHROOM2 shroom family member 2
SIX1 SIX homeobox 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC46A3 solute carrier family 46, member 3
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLITRK5 SLIT and NTRK-like family, member 5
SNHG3 small nucleolar RNA host gene 3
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRBD1 S1 RNA binding domain 1
STIM1 stromal interaction molecule 1
TAGLN3 transgelin 3
TEAD3 TEA domain family member 3
TESK2 testis-specific kinase 2
THBS3 thrombospondin 3
TMEM110 transmembrane protein 110
TMEM183A transmembrane protein 183A
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRIM45 tripartite motif containing 45
TRIM9 tripartite motif containing 9
TSPAN8 tetraspanin 8
TTC26 tetratricopeptide repeat domain 26
TUBA3C tubulin, alpha 3c
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WBP2 WW domain binding protein 2
ZBTB3 zinc finger and BTB domain containing 3
ZBTB48 zinc finger and BTB domain containing 48
ZNF189 zinc finger protein 189
ZNF33B zinc finger protein 33B
ZNF668 zinc finger protein 668
ZNF747 zinc finger protein 747
ZNF85 zinc finger protein 85