secretory granule lumen Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description The volume enclosed by the membrane of a secretory granule. (Gene Ontology, GO_0034774)
External Link http://amigo.geneontology.org/amigo/term/GO:0034774
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Genes

317 proteins localized to the secretory granule lumen cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
A1BG alpha-1-B glycoprotein
A2M alpha-2-macroglobulin
ACAA1 acetyl-CoA acyltransferase 1
ACLY ATP citrate lyase
ACTN1 actinin, alpha 1
ACTN2 actinin, alpha 2
ACTN4 actinin, alpha 4
ACTR10 actin-related protein 10 homolog (S. cerevisiae)
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADA2 adenosine deaminase 2
ADM adrenomedullin
AGA aspartylglucosaminidase
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHSG alpha-2-HS-glycoprotein
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2
ALAD aminolevulinate dehydratase
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AMPD3 adenosine monophosphate deaminase 3
ANKRD44 ankyrin repeat domain 44
ANXA2 annexin A2
AOC1 amine oxidase, copper containing 1
APAF1 apoptotic peptidase activating factor 1
APOA1 apolipoprotein A-I
APOH apolipoprotein H (beta-2-glycoprotein I)
APOOL apolipoprotein O-like
APP amyloid beta (A4) precursor protein
APRT adenine phosphoribosyltransferase
ARHGAP45 Rho GTPase activating protein 45
ARHGAP9 Rho GTPase activating protein 9
ARMC8 armadillo repeat containing 8
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARSA arylsulfatase A
ATG7 autophagy related 7
AZU1 azurocidin 1
B2M beta-2-microglobulin
BIN2 bridging integrator 2
BPI bactericidal/permeability-increasing protein
C1ORF35 chromosome 1 open reading frame 35
C1QTNF1 C1q and tumor necrosis factor related protein 1
C3 complement component 3
C6ORF120 chromosome 6 open reading frame 120
CAB39 calcium binding protein 39
CAND1 cullin-associated and neddylation-dissociated 1
CANT1 calcium activated nucleotidase 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDA cytidine deaminase
CDC37L1 cell division cycle 37-like 1
CEP290 centrosomal protein 290kDa
CFP complement factor properdin
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIT1 chitinase 1 (chitotriosidase)
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
CNN2 calponin 2
COMMD9 COMM domain containing 9
COTL1 coactosin-like F-actin binding protein 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRACR2A calcium release activated channel regulator 2A
CREG1 cellular repressor of E1A-stimulated genes 1
CRISP3 cysteine-rich secretory protein 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSNK2B casein kinase 2, beta polypeptide
CSTB cystatin B (stefin B)
CTSA cathepsin A
CTSC cathepsin C
CTSD cathepsin D
CTSG cathepsin G
CTSH cathepsin H
CTSW cathepsin W
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYB5R3 cytochrome b5 reductase 3
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYRIB CYFIP related Rac1 interactor B
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DBNL drebrin-like
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DEFA1 defensin, alpha 1
DEFA3 defensin, alpha 3, neutrophil-specific
DEFA4 defensin, alpha 4, corticostatin
DEFA5 defensin, alpha 5, Paneth cell-specific
DERA deoxyribose-phosphate aldolase (putative)
DLC1 DLC1 Rho GTPase activating protein
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNASE1L1 deoxyribonuclease I-like 1
DOCK2 dedicator of cytokinesis 2
DPP7 dipeptidyl-peptidase 7
DSN1 DSN1, MIS12 kinetochore complex component
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNLT1 dynein, light chain, Tctex-type 1
ECM1 extracellular matrix protein 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF2 eukaryotic translation elongation factor 2
EGF epidermal growth factor
EGFL7 EGF-like-domain, multiple 7
ELANE elastase, neutrophil expressed
EPX eosinophil peroxidase
ERP44 endoplasmic reticulum protein 44
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAF2 Fas associated factor family member 2
FAM3C family with sequence similarity 3, member C
FBF1 Fas (TNFRSF6) binding factor 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FERMT3 fermitin family member 3
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FGR FGR proto-oncogene, Src family tyrosine kinase
FN1 fibronectin 1
FOLR3 folate receptor 3 (gamma)
FRK fyn-related Src family tyrosine kinase
FTL ferritin, light polypeptide
FUCA1 fucosidase, alpha-L- 1, tissue
FUCA2 fucosidase, alpha-L- 2, plasma
GALNS galactosamine (N-acetyl)-6-sulfatase
GAS6 growth arrest-specific 6
GCA grancalcin, EF-hand calcium binding protein
GCG glucagon
GDI2 GDP dissociation inhibitor 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHDC GH3 domain containing
GHRL ghrelin/obestatin prepropeptide
GLB1 galactosidase, beta 1
GLYAT glycine-N-acyltransferase
GM2A GM2 ganglioside activator
GMFG glia maturation factor, gamma
GNPDA1 glucosamine-6-phosphate deaminase 1
GNS glucosamine (N-acetyl)-6-sulfatase
GRN granulin
GSDMD gasdermin D
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
GTPBP2 GTP binding protein 2
GUSB glucuronidase, beta
GYG1 glycogenin 1
HEBP2 heme binding protein 2
HEXB hexosaminidase B (beta polypeptide)
HMGB1 high mobility group box 1
HOOK3 hook microtubule-tethering protein 3
HPSE heparanase
HRNR hornerin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
ILF2 interleukin enhancer binding factor 2
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INS insulin
ISLR immunoglobulin superfamily containing leucine-rich repeat
IST1 increased sodium tolerance 1 homolog (yeast)
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
JUP junction plakoglobin
KNG1 kininogen 1
KPNB1 karyopherin (importin) beta 1
LCN2 lipocalin 2
LEFTY2 left-right determination factor 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC112694756 uncharaterized LOC112694756
LRG1 leucine-rich alpha-2-glycoprotein 1
LRRC7 leucine rich repeat containing 7
LTF lactotransferrin
LYZ lysozyme
MAGED2 melanoma antigen family D2
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MMP8 matrix metallopeptidase 8
MMRN1 multimerin 1
MNDA myeloid cell nuclear differentiation antigen
MPO myeloperoxidase
MVP major vault protein
NAPRT nicotinate phosphoribosyltransferase
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHLRC2 NHL repeat containing 2
NHLRC3 NHL repeat containing 3
NIT2 nitrilase family, member 2
NME2 NME/NM23 nucleoside diphosphate kinase 2
NPC2 Niemann-Pick disease, type C2
OLA1 Obg-like ATPase 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
ORM2 orosomucoid 2
OSCAR osteoclast associated, immunoglobulin-like receptor
OSTF1 osteoclast stimulating factor 1
PA2G4 proliferation-associated 2G4, 38kDa
PADI2 peptidyl arginine deiminase, type II
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PCSK1 proprotein convertase subtilisin/kexin type 1
PCYOX1L prenylcysteine oxidase 1 like
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PF4 platelet factor 4
PFKL phosphofructokinase, liver
PGAM4 phosphoglycerate mutase family member 4
PGLYRP1 peptidoglycan recognition protein 1
PGM2 phosphoglucomutase 2
PIKFYVE phosphoinositide kinase, FYVE finger containing
PKM pyruvate kinase, muscle
PLAC8 placenta-specific 8
PLG plasminogen
POMC proopiomelanocortin
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPIE peptidylprolyl isomerase E (cyclophilin E)
PPY pancreatic polypeptide
PRDX4 peroxiredoxin 4
PRDX5 peroxiredoxin 5
PRKCD protein kinase C, delta
PROS1 protein S (alpha)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS57 protease, serine, 57
PRTN3 proteinase 3
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PTGES2 prostaglandin E synthase 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTX3 pentraxin 3, long
PYCARD PYD and CARD domain containing
PYGB phosphorylase, glycogen; brain
PYGL phosphorylase, glycogen, liver
QPCT glutaminyl-peptide cyclotransferase
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB27A RAB27A, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RETN resistin
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNASET2 ribonuclease T2
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
S100A11 S100 calcium binding protein A11
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCCPDH saccharopine dehydrogenase (putative)
SCG3 secretogranin III
SDCBP syndecan binding protein (syntenin)
SELENOP selenoprotein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGPP2 sphingosine-1-phosphate phosphatase 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SOS1 son of sevenless homolog 1 (Drosophila)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRGN serglycin
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
STK11IP serine/threonine kinase 11 interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX264 testis expressed 264
TF transferrin
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMSB4X thymosin beta 4, X-linked
TOLLIP toll interacting protein
TOR4A torsin family 4, member A
TRAPPC1 trafficking protein particle complex 1
TTR transthyretin
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UCMA upper zone of growth plate and cartilage matrix associated
UNC13D unc-13 homolog D (C. elegans)
VAT1 vesicle amine transport 1
VCL vinculin
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
VEGFD vascular endothelial growth factor D
VTI1B vesicle transport through interaction with t-SNAREs 1B
VWF von Willebrand factor
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6