securinine-2729 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the securinine-2729 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AJAP1 adherens junctions associated protein 1
ANGEL2 angel homolog 2 (Drosophila)
ANGPT1 angiopoietin 1
APOM apolipoprotein M
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP10A ATPase, class V, type 10A
BAG3 BCL2-associated athanogene 3
BIN1 bridging integrator 1
CD34 CD34 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL17A1 collagen, type XVII, alpha 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DCTN2 dynactin 2 (p50)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EGR1 early growth response 1
ELSPBP1 epididymal sperm binding protein 1
EML3 echinoderm microtubule associated protein like 3
EPHA5 EPH receptor A5
F11 coagulation factor XI
FCAR Fc fragment of IgA receptor
GAS8 growth arrest-specific 8
GCLM glutamate-cysteine ligase, modifier subunit
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
HIST1H4G histone cluster 1, H4g
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
HPCAL4 hippocalcin like 4
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IGF1R insulin-like growth factor 1 receptor
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL6ST interleukin 6 signal transducer
INSL5 insulin-like 5
IRF4 interferon regulatory factor 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIF24 kinesin family member 24
KLF6 Kruppel-like factor 6
KRT2 keratin 2, type II
KRT6B keratin 6B, type II
LAMP1 lysosomal-associated membrane protein 1
LEPR leptin receptor
LOC100131613 PRO1454
MAMLD1 mastermind-like domain containing 1
MAPT microtubule-associated protein tau
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MUC3B mucin 3B, cell surface associated
MYH10 myosin, heavy chain 10, non-muscle
NECAB2 N-terminal EF-hand calcium binding protein 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRF1 nuclear respiratory factor 1
NUP214 nucleoporin 214kDa
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAX4 paired box 4
PCDHGA10 protocadherin gamma subfamily A, 10
PDE4D phosphodiesterase 4D, cAMP-specific
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLEK2 pleckstrin 2
PQLC2 PQ loop repeat containing 2
PURA purine-rich element binding protein A
RAB11B RAB11B, member RAS oncogene family
REEP2 receptor accessory protein 2
RGS5 regulator of G-protein signaling 5
RIT1 Ras-like without CAAX 1
RPL23AP53 ribosomal protein L23a pseudogene 53
S100A3 S100 calcium binding protein A3
SARM1 sterile alpha and TIR motif containing 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNPH syntaphilin
SQSTM1 sequestosome 1
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STK17A serine/threonine kinase 17a
TAS2R1 taste receptor, type 2, member 1
TMEM2 transmembrane protein 2
TMPRSS6 transmembrane protease, serine 6
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRD T cell receptor delta locus
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
UBOX5 U-box domain containing 5
UNKL unkempt family zinc finger-like
ZNF205 zinc finger protein 205
ZNF407 zinc finger protein 407

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACP6 acid phosphatase 6, lysophosphatidic
ADGRE2 adhesion G protein-coupled receptor E2
ADRB2 adrenoceptor beta 2, surface
AEN apoptosis enhancing nuclease
AMT aminomethyltransferase
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASIC1 acid sensing (proton gated) ion channel 1
BACE1 beta-site APP-cleaving enzyme 1
BAHCC1 BAH domain and coiled-coil containing 1
BAMBI BMP and activin membrane-bound inhibitor
BPHL biphenyl hydrolase-like (serine hydrolase)
C11ORF21 chromosome 11 open reading frame 21
C1ORF106 chromosome 1 open reading frame 106
CCND1 cyclin D1
CD1D CD1d molecule
CD3EAP CD3e molecule, epsilon associated protein
CD82 CD82 molecule
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CUL9 cullin 9
CX3CR1 chemokine (C-X3-C motif) receptor 1
DENND5B DENN/MADD domain containing 5B
DIXDC1 DIX domain containing 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DZANK1 double zinc ribbon and ankyrin repeat domains 1
E2F1 E2F transcription factor 1
ECI2 enoyl-CoA delta isomerase 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV4 ets variant 4
FANCF Fanconi anemia, complementation group F
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GPR85 G protein-coupled receptor 85
GPRC5C G protein-coupled receptor, class C, group 5, member C
GSDMD gasdermin D
HIST1H2AG histone cluster 1, H2ag
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
ICAM2 intercellular adhesion molecule 2
IPO8 importin 8
IRF8 interferon regulatory factor 8
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JUP junction plakoglobin
KIAA1024 KIAA1024
KIAA1107 KIAA1107
KLHL26 kelch-like family member 26
LHFP lipoma HMGIC fusion partner
MAGEH1 melanoma antigen family H1
MANSC1 MANSC domain containing 1
METTL16 methyltransferase like 16
MT1HL1 metallothionein 1H-like 1
MX2 MX dynamin-like GTPase 2
NFE2 nuclear factor, erythroid 2
NFE2L3 nuclear factor, erythroid 2-like 3
NRGN neurogranin (protein kinase C substrate, RC3)
NTSR1 neurotensin receptor 1 (high affinity)
PCYOX1 prenylcysteine oxidase 1
PDZD7 PDZ domain containing 7
PGP phosphoglycolate phosphatase
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLTP phospholipid transfer protein
PPAN peter pan homolog (Drosophila)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTX3 pentraxin 3, long
RGS16 regulator of G-protein signaling 16
RNF144A ring finger protein 144A
RSAD1 radical S-adenosyl methionine domain containing 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SATB1 SATB homeobox 1
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SH2D4A SH2 domain containing 4A
SIK1 salt-inducible kinase 1
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLITRK5 SLIT and NTRK-like family, member 5
SMAD7 SMAD family member 7
SPINT1 serine peptidase inhibitor, Kunitz type 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TGM5 transglutaminase 5
THBS4 thrombospondin 4
TMEM45A transmembrane protein 45A
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNS3 tensin 3
TRIM5 tripartite motif containing 5
TRIM9 tripartite motif containing 9
TSPAN32 tetraspanin 32
TSPYL2 TSPY-like 2
TUBGCP5 tubulin, gamma complex associated protein 5
WNT10B wingless-type MMTV integration site family, member 10B
ZC4H2 zinc finger, C4H2 domain containing
ZNF74 zinc finger protein 74
ZNF862 zinc finger protein 862