selegiline-4065 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the selegiline-4065 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIM1L absent in melanoma 1-like
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ARMC4 armadillo repeat containing 4
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BCHE butyrylcholinesterase
C8ORF44 chromosome 8 open reading frame 44
CACFD1 calcium channel flower domain containing 1
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CCDC28B coiled-coil domain containing 28B
CD1E CD1e molecule
CDK10 cyclin-dependent kinase 10
CEP295 centrosomal protein 295kDa
CLCN4 chloride channel, voltage-sensitive 4
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DAAM2 dishevelled associated activator of morphogenesis 2
DCAF11 DDB1 and CUL4 associated factor 11
DCAF15 DDB1 and CUL4 associated factor 15
DGCR8 DGCR8 microprocessor complex subunit
DHODH dihydroorotate dehydrogenase (quinone)
DKFZP434C153 DKFZP434C153 protein
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EMC3 ER membrane protein complex subunit 3
ESRRG estrogen-related receptor gamma
FABP3 fatty acid binding protein 3, muscle and heart
FAS Fas cell surface death receptor
FCAR Fc fragment of IgA receptor
FLT1 fms-related tyrosine kinase 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPER1 G protein-coupled estrogen receptor 1
GSPT1 G1 to S phase transition 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HNF4A hepatocyte nuclear factor 4, alpha
HRASLS2 HRAS-like suppressor 2
HSF1 heat shock transcription factor 1
ICOSLG inducible T-cell co-stimulator ligand
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
IRS4 insulin receptor substrate 4
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KALRN kalirin, RhoGEF kinase
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KERA keratocan
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAPK11 mitogen-activated protein kinase 11
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MSR1 macrophage scavenger receptor 1
MST1L macrophage stimulating 1-like
NCOR2 nuclear receptor corepressor 2
NME5 NME/NM23 family member 5
OTUD4 OTU deubiquitinase 4
PBX1 pre-B-cell leukemia homeobox 1
PCDH11Y protocadherin 11 Y-linked
PGLYRP1 peptidoglycan recognition protein 1
PHF14 PHD finger protein 14
PHF3 PHD finger protein 3
PHF8 PHD finger protein 8
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCD1 phospholipase C, delta 1
PLK4 polo-like kinase 4
PPARD peroxisome proliferator-activated receptor delta
PRSS8 protease, serine, 8
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
REC8 REC8 meiotic recombination protein
RFPL3S RFPL3 antisense
RNF32 ring finger protein 32
RPL10 ribosomal protein L10
RPS14 ribosomal protein S14
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAFB scaffold attachment factor B
SCAPER S-phase cyclin A-associated protein in the ER
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SOSTDC1 sclerostin domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYT5 synaptotagmin V
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAS2R14 taste receptor, type 2, member 14
TBX1 T-box 1
TBXA2R thromboxane A2 receptor
TCF3 transcription factor 3
TFCP2L1 transcription factor CP2-like 1
TP53I11 tumor protein p53 inducible protein 11
TRIL TLR4 interactor with leucine-rich repeats
TRIM3 tripartite motif containing 3
TUBGCP2 tubulin, gamma complex associated protein 2
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UST uronyl-2-sulfotransferase
ZNF234 zinc finger protein 234

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMH anti-Mullerian hormone
ANKRD7 ankyrin repeat domain 7
ANP32A-IT1 ANP32A intronic transcript 1
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ASTN1 astrotactin 1
ATAD5 ATPase family, AAA domain containing 5
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BMP10 bone morphogenetic protein 10
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF105 chromosome 14 open reading frame 105
CASP5 caspase 5, apoptosis-related cysteine peptidase
CD79B CD79b molecule, immunoglobulin-associated beta
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLDN17 claudin 17
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
DPYS dihydropyrimidinase
DSPP dentin sialophosphoprotein
DTX2 deltex 2, E3 ubiquitin ligase
EFCAB2 EF-hand calcium binding domain 2
EXD3 exonuclease 3'-5' domain containing 3
EXO5 exonuclease 5
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM120C family with sequence similarity 120C
FGF23 fibroblast growth factor 23
FRS3 fibroblast growth factor receptor substrate 3
FURIN furin (paired basic amino acid cleaving enzyme)
GRM4 glutamate receptor, metabotropic 4
HAMP hepcidin antimicrobial peptide
HHAT hedgehog acyltransferase
HIST1H1D histone cluster 1, H1d
HIST1H2AB histone cluster 1, H2ab
HIST1H2BN histone cluster 1, H2bn
HSPA1L heat shock 70kDa protein 1-like
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFT140 intraflagellar transport 140
IFT54 intraflagellar transport 54
IL18R1 interleukin 18 receptor 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL36RN interleukin 36 receptor antagonist
IQSEC2 IQ motif and Sec7 domain 2
KIAA0319L KIAA0319-like
LIME1 Lck interacting transmembrane adaptor 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LUM lumican
LY6D lymphocyte antigen 6 complex, locus D
MGP matrix Gla protein
MILR1 mast cell immunoglobulin-like receptor 1
MRPS18C mitochondrial ribosomal protein S18C
MTCP1 mature T-cell proliferation 1
MTSS1L metastasis suppressor 1-like
NIPAL2 NIPA-like domain containing 2
NOL4 nucleolar protein 4
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
ORAI3 ORAI calcium release-activated calcium modulator 3
OXCT2 3-oxoacid CoA transferase 2
PACS1 phosphofurin acidic cluster sorting protein 1
PAQR4 progestin and adipoQ receptor family member IV
PBOV1 prostate and breast cancer overexpressed 1
PCDHA5 protocadherin alpha 5
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEX5L peroxisomal biogenesis factor 5-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPSN receptor-associated protein of the synapse
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGCC regulator of cell cycle
RIBC2 RIB43A domain with coiled-coils 2
RNF2 ring finger protein 2
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A1 secretoglobin, family 2A, member 1
SCN1B sodium channel, voltage gated, type I beta subunit
SLC16A6 solute carrier family 16, member 6
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SPTBN2 spectrin, beta, non-erythrocytic 2
STIM1 stromal interaction molecule 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TCEAL2 transcription elongation factor A (SII)-like 2
TENM4 teneurin transmembrane protein 4
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THRAP3 thyroid hormone receptor associated protein 3
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TSPYL2 TSPY-like 2
TUBA4B tubulin, alpha 4b
USP20 ubiquitin specific peptidase 20
ZBTB22 zinc finger and BTB domain containing 22
ZIC3 Zic family member 3
ZNF253 zinc finger protein 253
ZNF280A zinc finger protein 280A
ZNF408 zinc finger protein 408
ZNF428 zinc finger protein 428
ZNF862 zinc finger protein 862
ZXDB zinc finger, X-linked, duplicated B