selegiline-4146 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the selegiline-4146 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD2 adducin 2 (beta)
AIM2 absent in melanoma 2
ARMC4 armadillo repeat containing 4
ARSA arylsulfatase A
BCAM basal cell adhesion molecule (Lutheran blood group)
BST2 bone marrow stromal cell antigen 2
C10ORF12 chromosome 10 open reading frame 12
C17ORF59 chromosome 17 open reading frame 59
C6 complement component 6
C7ORF69 chromosome 7 open reading frame 69
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALB1 calbindin 1, 28kDa
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCKAR cholecystokinin A receptor
CCL19 chemokine (C-C motif) ligand 19
CCND2 cyclin D2
CD248 CD248 molecule, endosialin
CD7 CD7 molecule
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CFAP69 cilia and flagella associated protein 69
CFDP1 craniofacial development protein 1
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DFNB31 deafness, autosomal recessive 31
DOCK10 dedicator of cytokinesis 10
DOCK6 dedicator of cytokinesis 6
DRD2 dopamine receptor D2
DTX2 deltex 2, E3 ubiquitin ligase
DVL2 dishevelled segment polarity protein 2
EHD2 EH-domain containing 2
EPS8L3 EPS8-like 3
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GIF gastric intrinsic factor (vitamin B synthesis)
GP2 glycoprotein 2 (zymogen granule membrane)
HOXA11 homeobox A11
HOXA7 homeobox A7
HOXB5 homeobox B5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IFNA14 interferon, alpha 14
IMPG2 interphotoreceptor matrix proteoglycan 2
INO80D INO80 complex subunit D
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KIF21B kinesin family member 21B
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KMT2A lysine (K)-specific methyltransferase 2A
KRT24 keratin 24, type I
LINC00652 long intergenic non-protein coding RNA 652
LMO3 LIM domain only 3 (rhombotin-like 2)
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LTBP4 latent transforming growth factor beta binding protein 4
MARK4 MAP/microtubule affinity-regulating kinase 4
MBD2 methyl-CpG binding domain protein 2
MED18 mediator complex subunit 18
MX2 MX dynamin-like GTPase 2
NCOR2 nuclear receptor corepressor 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXDC1 plexin domain containing 1
POFUT1 protein O-fucosyltransferase 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PON3 paraoxonase 3
PPP1R37 protein phosphatase 1, regulatory subunit 37
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
RABGAP1 RAB GTPase activating protein 1
RBP4 retinol binding protein 4, plasma
RPL35A ribosomal protein L35a
SERHL2 serine hydrolase-like 2
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SIX3 SIX homeobox 3
SOCS1 suppressor of cytokine signaling 1
SP100 SP100 nuclear antigen
SP110 SP110 nuclear body protein
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
TBCD tubulin folding cofactor D
TSPAN32 tetraspanin 32
TTC9 tetratricopeptide repeat domain 9
TUBA4B tubulin, alpha 4b
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
USP22 ubiquitin specific peptidase 22
WNT2B wingless-type MMTV integration site family, member 2B
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ALS2CL ALS2 C-terminal like
AMT aminomethyltransferase
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOLD1 apolipoprotein L domain containing 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARRB1 arrestin, beta 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHCC1 BAH domain and coiled-coil containing 1
C11ORF80 chromosome 11 open reading frame 80
C14ORF79 chromosome 14 open reading frame 79
C2ORF27A chromosome 2 open reading frame 27A
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC71 coiled-coil domain containing 71
CD8A CD8a molecule
CDHR2 cadherin-related family member 2
CENPO centromere protein O
CHML choroideremia-like (Rab escort protein 2)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLSTN2 calsyntenin 2
CNR2 cannabinoid receptor 2 (macrophage)
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CPB2 carboxypeptidase B2 (plasma)
CRY2 cryptochrome circadian clock 2
CTAGE9 CTAGE family, member 9
CUL9 cullin 9
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
DNM3 dynamin 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK1 dedicator of cytokinesis 1
DYSF dysferlin
EGFL7 EGF-like-domain, multiple 7
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EXOC6B exocyst complex component 6B
FAM76A family with sequence similarity 76, member A
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR182 G protein-coupled receptor 182
GTF2I general transcription factor IIi
HDAC11 histone deacetylase 11
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
HOXC4 homeobox C4
HPS6 Hermansky-Pudlak syndrome 6
IFNA17 interferon, alpha 17
IGSF1 immunoglobulin superfamily, member 1
IL22 interleukin 22
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNIP1 Kv channel interacting protein 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0355 KIAA0355
KIAA1024 KIAA1024
LAMA3 laminin, alpha 3
LATS1 large tumor suppressor kinase 1
LOC729164 hCG1732469
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAST3 microtubule associated serine/threonine kinase 3
MATK megakaryocyte-associated tyrosine kinase
MOB3B MOB kinase activator 3B
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OR2B6 olfactory receptor, family 2, subfamily B, member 6
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PRF1 perforin 1 (pore forming protein)
PSG4 pregnancy specific beta-1-glycoprotein 4
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRM protein tyrosine phosphatase, receptor type, M
RASL11B RAS-like, family 11, member B
RFPL3 ret finger protein-like 3
RNF208 ring finger protein 208
SETD8 SET domain containing (lysine methyltransferase) 8
SKI SKI proto-oncogene
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SREK1IP1 SREK1-interacting protein 1
STARD3 StAR-related lipid transfer (START) domain containing 3
STK16 serine/threonine kinase 16
TBC1D19 TBC1 domain family, member 19
TMCC2 transmembrane and coiled-coil domain family 2
TMEM209 transmembrane protein 209
TRIM25 tripartite motif containing 25
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VASH2 vasohibin 2
VIPR1 vasoactive intestinal peptide receptor 1
VPS9D1 VPS9 domain containing 1
WDR78 WD repeat domain 78
YEATS2 YEATS domain containing 2
ZBTB22 zinc finger and BTB domain containing 22
ZNF205 zinc finger protein 205
ZNF750 zinc finger protein 750