sema3a Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A|This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10371)
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Genes

30 genes co-occuring with the biological term sema3a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ALK anaplastic lymphoma receptor tyrosine kinase
CD72 CD72 molecule
CIITA class II, major histocompatibility complex, transactivator
CXCL12 chemokine (C-X-C motif) ligand 12
EGF epidermal growth factor
EIF4E eukaryotic translation initiation factor 4E
FAS Fas cell surface death receptor
GSK3B glycogen synthase kinase 3 beta
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KDR kinase insert domain receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LRRC7 leucine rich repeat containing 7
NRP1 neuropilin 1
NRP2 neuropilin 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PLXNA1 plexin A1
PLXNA2 plexin A2
PLXNA3 plexin A3
REST RE1-silencing transcription factor
RHOA ras homolog family member A
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
STIP1 stress-induced phosphoprotein 1
TMEM132D transmembrane protein 132D
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)