semustine-7545 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the semustine-7545 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADGRB1 adhesion G protein-coupled receptor B1
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANGPTL4 angiopoietin-like 4
ARG2 arginase 2
ARTN artemin
ASB1 ankyrin repeat and SOCS box containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ASTN2 astrotactin 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAIAP2 BAI1-associated protein 2
BBC3 BCL2 binding component 3
BRAP BRCA1 associated protein
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF10 chromosome 10 open reading frame 10
CACFD1 calcium channel flower domain containing 1
CCPG1 cell cycle progression 1
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDKL3 cyclin-dependent kinase-like 3
CHD7 chromodomain helicase DNA binding protein 7
CPPED1 calcineurin-like phosphoesterase domain containing 1
CREM cAMP responsive element modulator
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CROCC ciliary rootlet coiled-coil, rootletin
CTNS cystinosin, lysosomal cystine transporter
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOLPP1 dolichyldiphosphatase 1
EFNB3 ephrin-B3
EPN1 epsin 1
FBXO21 F-box protein 21
FICD FIC domain containing
FLCN folliculin
FSTL3 follistatin-like 3 (secreted glycoprotein)
GABARAPL1 GABA(A) receptor-associated protein like 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HLX H2.0-like homeobox
HMOX1 heme oxygenase 1
HRK harakiri, BCL2 interacting protein
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA7 integrin, alpha 7
ITK IL2-inducible T-cell kinase
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL25 kelch-like family member 25
KRT6A keratin 6A, type II
LAMP1 lysosomal-associated membrane protein 1
LYPD3 LY6/PLAUR domain containing 3
LZTR1 leucine-zipper-like transcription regulator 1
MDFI MyoD family inhibitor
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MINK1 misshapen-like kinase 1
MPDZ multiple PDZ domain protein
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTHLH parathyroid hormone-like hormone
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB2A RAB2A, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
SAMD9 sterile alpha motif domain containing 9
SERHL2 serine hydrolase-like 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMG5 SMG5 nonsense mediated mRNA decay factor
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SRCAP Snf2-related CREBBP activator protein
STX2 syntaxin 2
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAOK2 TAO kinase 2
TRAPPC13 trafficking protein particle complex 13
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TUBA3C tubulin, alpha 3c
WDR4 WD repeat domain 4
ZNF446 zinc finger protein 446
ZNF749 zinc finger protein 749
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
BAK1 BCL2-antagonist/killer 1
BCAS3 breast carcinoma amplified sequence 3
CCDC85C coiled-coil domain containing 85C
CCL22 chemokine (C-C motif) ligand 22
CCNE2 cyclin E2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK6 cyclin-dependent kinase 6
CIR1 corepressor interacting with RBPJ, 1
CLDN1 claudin 1
CLSPN claspin
CORT cortistatin
CTGF connective tissue growth factor
DCAF4 DDB1 and CUL4 associated factor 4
EDC3 enhancer of mRNA decapping 3
EFCAB2 EF-hand calcium binding domain 2
EFNA3 ephrin-A3
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EPPK1 epiplakin 1
EPS8L3 EPS8-like 3
ERMP1 endoplasmic reticulum metallopeptidase 1
FAT4 FAT atypical cadherin 4
FGD6 FYVE, RhoGEF and PH domain containing 6
FJX1 four jointed box 1 (Drosophila)
GBX2 gastrulation brain homeobox 2
GCA grancalcin, EF-hand calcium binding protein
GLI3 GLI family zinc finger 3
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
H1F0 H1 histone family, member 0
HDAC5 histone deacetylase 5
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AM histone cluster 1, H2am
HIST1H3I histone cluster 1, H3i
HOXA2 homeobox A2
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IFNA14 interferon, alpha 14
IL1B interleukin 1, beta
IPO8 importin 8
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA1462 KIAA1462
KLF7 Kruppel-like factor 7 (ubiquitous)
LAX1 lymphocyte transmembrane adaptor 1
LMO7 LIM domain 7
LOC100294391 uncharacterized LOC100294391
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LRRC61 leucine rich repeat containing 61
MANEA mannosidase, endo-alpha
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MATN3 matrilin 3
METTL16 methyltransferase like 16
MN1 meningioma (disrupted in balanced translocation) 1
MOXD1 monooxygenase, DBH-like 1
MUC3B mucin 3B, cell surface associated
NEK11 NIMA-related kinase 11
NHLRC2 NHL repeat containing 2
NID2 nidogen 2 (osteonidogen)
NRSN2 neurensin 2
P3H2 prolyl 3-hydroxylase 2
PCOLCE procollagen C-endopeptidase enhancer
PDE12 phosphodiesterase 12
PDZK1 PDZ domain containing 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLK2 polo-like kinase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR3 proline rich 3
PTX3 pentraxin 3, long
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RPP25 ribonuclease P/MRP 25kDa subunit
SDC3 syndecan 3
SETBP1 SET binding protein 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC35F6 solute carrier family 35, member F6
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
SULT4A1 sulfotransferase family 4A, member 1
SYT17 synaptotagmin XVII
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRAPPC11 trafficking protein particle complex 11
UGT8 UDP glycosyltransferase 8
USP20 ubiquitin specific peptidase 20
WNT7A wingless-type MMTV integration site family, member 7A
XYLT2 xylosyltransferase II
ZNF33B zinc finger protein 33B
ZNF442 zinc finger protein 442
ZNF711 zinc finger protein 711