seneciphylline-2797 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the seneciphylline-2797 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM22 ADAM metallopeptidase domain 22
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ANXA2P3 annexin A2 pseudogene 3
ARNT aryl hydrocarbon receptor nuclear translocator
ART1 ADP-ribosyltransferase 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATG10 autophagy related 10
ATXN3 ataxin 3
BPIFA1 BPI fold containing family A, member 1
C1QTNF1 C1q and tumor necrosis factor related protein 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CD7 CD7 molecule
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CHI3L2 chitinase 3-like 2
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CLEC11A C-type lectin domain family 11, member A
CLIC5 chloride intracellular channel 5
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL9 cullin 9
DCN decorin
DLL3 delta-like 3 (Drosophila)
ELAC2 elaC ribonuclease Z 2
EMC1 ER membrane protein complex subunit 1
EPHA1 EPH receptor A1
FBXO41 F-box protein 41
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF5 fibroblast growth factor 5
FGR FGR proto-oncogene, Src family tyrosine kinase
FH fumarate hydratase
FLJ20712 uncharacterized FLJ20712
FLJ22184
FOSL1 FOS-like antigen 1
FOXP3 forkhead box P3
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GFER growth factor, augmenter of liver regeneration
GMPR guanosine monophosphate reductase
GSK3A glycogen synthase kinase 3 alpha
HPS1 Hermansky-Pudlak syndrome 1
IL2RG interleukin 2 receptor, gamma
INHBE inhibin, beta E
ITPKB inositol-trisphosphate 3-kinase B
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD17 potassium channel tetramerization domain containing 17
KLHL25 kelch-like family member 25
LAMC2 laminin, gamma 2
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LPPR2 lipid phosphate phosphatase-related protein type 2
LTBP4 latent transforming growth factor beta binding protein 4
MAL mal, T-cell differentiation protein
MAP2K5 mitogen-activated protein kinase kinase 5
MAP4 microtubule-associated protein 4
MTSS1 metastasis suppressor 1
MXD4 MAX dimerization protein 4
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NR6A1 nuclear receptor subfamily 6, group A, member 1
ONECUT2 one cut homeobox 2
OR1F1 olfactory receptor, family 1, subfamily F, member 1
PACS1 phosphofurin acidic cluster sorting protein 1
PAX5 paired box 5
PCDHB12 protocadherin beta 12
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE8B phosphodiesterase 8B
PITX1 paired-like homeodomain 1
PKNOX2 PBX/knotted 1 homeobox 2
POM121L2 POM121 transmembrane nucleoporin-like 2
POU2F3 POU class 2 homeobox 3
PPP5C protein phosphatase 5, catalytic subunit
PRPH2 peripherin 2 (retinal degeneration, slow)
PTHLH parathyroid hormone-like hormone
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBMS2 RNA binding motif, single stranded interacting protein 2
RGS12 regulator of G-protein signaling 12
RUFY3 RUN and FYVE domain containing 3
S100A9 S100 calcium binding protein A9
SGSH N-sulfoglucosamine sulfohydrolase
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
STK10 serine/threonine kinase 10
STK24 serine/threonine kinase 24
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TAGLN3 transgelin 3
TGFB1 transforming growth factor, beta 1
TJAP1 tight junction associated protein 1 (peripheral)
TLDC1 TBC/LysM-associated domain containing 1
UBE3A ubiquitin protein ligase E3A
UGT8 UDP glycosyltransferase 8
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VAC14 Vac14 homolog (S. cerevisiae)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZBTB7A zinc finger and BTB domain containing 7A
ZC3H3 zinc finger CCCH-type containing 3
ZC3H7B zinc finger CCCH-type containing 7B
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF446 zinc finger protein 446

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ANAPC2 anaphase promoting complex subunit 2
APOLD1 apolipoprotein L domain containing 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BAGE B melanoma antigen
BAX BCL2-associated X protein
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C17ORF80 chromosome 17 open reading frame 80
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNT1 cyclin T1
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK20 cyclin-dependent kinase 20
CLCN5 chloride channel, voltage-sensitive 5
CRABP1 cellular retinoic acid binding protein 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDA1 DET1 and DDB1 associated 1
DEAF1 DEAF1 transcription factor
DGKE diacylglycerol kinase, epsilon 64kDa
DUSP2 dual specificity phosphatase 2
EIF5A2 eukaryotic translation initiation factor 5A2
ERCC4 excision repair cross-complementation group 4
ERF Ets2 repressor factor
ETAA1 Ewing tumor-associated antigen 1
FAM188A family with sequence similarity 188, member A
FAM204A family with sequence similarity 204, member A
FBXO5 F-box protein 5
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GLS2 glutaminase 2 (liver, mitochondrial)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GTF2I general transcription factor IIi
H1F0 H1 histone family, member 0
HIST1H2AJ histone cluster 1, H2aj
HIST1H3E histone cluster 1, H3e
HP1BP3 heterochromatin protein 1, binding protein 3
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IDI2-AS1 IDI2 antisense RNA 1
IRX4 iroquois homeobox 4
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCTD20 potassium channel tetramerization domain containing 20
KIAA0125 KIAA0125
KPTN kaptin (actin binding protein)
LGMN legumain
LMNB1 lamin B1
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LYPD1 LY6/PLAUR domain containing 1
MDM4 MDM4, p53 regulator
METTL16 methyltransferase like 16
MGC12488
MPDU1 mannose-P-dolichol utilization defect 1
MSRA methionine sulfoxide reductase A
MTMR6 myotubularin related protein 6
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL5 myosin, light chain 5, regulatory
NFE2L3 nuclear factor, erythroid 2-like 3
NME6 NME/NM23 nucleoside diphosphate kinase 6
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
NUP62CL nucleoporin 62kDa C-terminal like
PARD6B par-6 family cell polarity regulator beta
PCDHA9 protocadherin alpha 9
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRR3 proline rich 3
PRSS16 protease, serine, 16 (thymus)
PSENEN presenilin enhancer gamma secretase subunit
RAB30 RAB30, member RAS oncogene family
RANGRF RAN guanine nucleotide release factor
RBM42 RNA binding motif protein 42
RPS10P5 ribosomal protein S10 pseudogene 5
SCYL2 SCY1-like 2 (S. cerevisiae)
SENP7 SUMO1/sentrin specific peptidase 7
SIX1 SIX homeobox 1
SLC46A3 solute carrier family 46, member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNORA21 small nucleolar RNA, H/ACA box 21
SPRYD7 SPRY domain containing 7
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STK16 serine/threonine kinase 16
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARP TCR gamma alternate reading frame protein
TEAD3 TEA domain family member 3
TK1 thymidine kinase 1, soluble
TMEM208 transmembrane protein 208
TMEM209 transmembrane protein 209
TRIM21 tripartite motif containing 21
TSSC4 tumor suppressing subtransferable candidate 4
UBXN8 UBX domain protein 8
ULBP2 UL16 binding protein 2
USP27X ubiquitin specific peptidase 27, X-linked
VASH2 vasohibin 2
ZBTB6 zinc finger and BTB domain containing 6
ZMAT5 zinc finger, matrin-type 5
ZNF480 zinc finger protein 480