senescence-associated heterochromatin focus Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes. (Gene Ontology, GO_0035985)
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Genes

4 proteins localized to the senescence-associated heterochromatin focus cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.663342
HMGA1 high mobility group AT-hook 1 0.663342
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.663342
CDKN2A cyclin-dependent kinase inhibitor 2A 0.663342
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