senescence Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

452 genes co-occuring with the biological term senescence in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABI3BP ABI family, member 3 (NESH) binding protein
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACLY ATP citrate lyase
ADA adenosine deaminase
AGER advanced glycosylation end product-specific receptor
AGO2 argonaute RISC catalytic component 2
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AIM2 absent in melanoma 2
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
ANK2 ankyrin 2, neuronal
ANXA5 annexin A5
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
ARF1 ADP-ribosylation factor 1
ARHGAP18 Rho GTPase activating protein 18
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASS1 argininosuccinate synthase 1
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
ATF7IP activating transcription factor 7 interacting protein
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AURKB aurora kinase B
B3GAT1 beta-1,3-glucuronyltransferase 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL6 B-cell CLL/lymphoma 6
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRD7 bromodomain containing 7
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C11ORF31 chromosome 11 open reading frame 31
CALCA calcitonin-related polypeptide alpha
CARM1 coactivator-associated arginine methyltransferase 1
CAV1 caveolin 1, caveolae protein, 22kDa
CBS cystathionine-beta-synthase
CBX4 chromobox homolog 4
CCNB1 cyclin B1
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2AIP CDKN2A interacting protein
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CENPA centromere protein A
CHD5 chromodomain helicase DNA binding protein 5
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CKB creatine kinase, brain
CLU clusterin
CNOT6 CCR4-NOT transcription complex, subunit 6
CNOT6L CCR4-NOT transcription complex, subunit 6-like
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRTC1 CREB regulated transcription coactivator 1
CRTC2 CREB regulated transcription coactivator 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSD cathepsin D
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAXX death-domain associated protein
DEK DEK proto-oncogene
DGCR8 DGCR8 microprocessor complex subunit
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNM1L dynamin 1-like
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPY30 dpy-30 homolog (C. elegans)
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
E2F7 E2F transcription factor 7
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EHF ets homologous factor
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
ELN elastin
ENG endoglin
EP400 E1A binding protein p400
ERBB2 erb-b2 receptor tyrosine kinase 2
EREG epiregulin
ERGIC2 ERGIC and golgi 2
ERRFI1 ERBB receptor feedback inhibitor 1
ESR2 estrogen receptor 2 (ER beta)
EWSR1 EWS RNA-binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCD2 Fanconi anemia, complementation group D2
FGF2 fibroblast growth factor 2 (basic)
FGF23 fibroblast growth factor 23
FGFR2 fibroblast growth factor receptor 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMR1 fragile X mental retardation 1
FOXA1 forkhead box A1
FOXA2 forkhead box A2
FOXA3 forkhead box A3
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GADD45G growth arrest and DNA-damage-inducible, gamma
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GJA1 gap junction protein, alpha 1, 43kDa
GLB1 galactosidase, beta 1
GLI2 GLI family zinc finger 2
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPI glucose-6-phosphate isomerase
GSK3B glycogen synthase kinase 3 beta
GUCY2C guanylate cyclase 2C
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HAS2 hyaluronan synthase 2
HAVCR2 hepatitis A virus cellular receptor 2
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HDAC1 histone deacetylase 1
HELLS helicase, lymphoid-specific
HEPACAM hepatic and glial cell adhesion molecule
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HJURP Holliday junction recognition protein
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOPX HOP homeobox
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI16 interferon, gamma-inducible protein 16
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL11 interleukin 11
IL12B interleukin 12B
IL15 interleukin 15
IL21 interleukin 21
IL4 interleukin 4
IL6 interleukin 6
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
ITGB4 integrin, beta 4
JAK2 Janus kinase 2
JDP2 Jun dimerization protein 2
KAT5 K(lysine) acetyltransferase 5
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KDM2B lysine (K)-specific demethylase 2B
KDM6B lysine (K)-specific demethylase 6B
KIAA1524 KIAA1524
KIF2C kinesin family member 2C
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1
KNG1 kininogen 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT5 keratin 5, type II
LAMA5 laminin, alpha 5
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LGALS9 lectin, galactoside-binding, soluble, 9
LIN9 lin-9 DREAM MuvB core complex component
LMNA lamin A/C
LMNB1 lamin B1
LOX lysyl oxidase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L1BP MAD2L1 binding protein
MAML1 mastermind-like 1 (Drosophila)
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK1 mitogen-activated protein kinase 1
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCH5 membrane-associated ring finger (C3HC4) 5
MCL1 myeloid cell leukemia 1
MCM2 minichromosome maintenance complex component 2
MCM3AP minichromosome maintenance complex component 3 associated protein
MCRS1 microspherule protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MEOX2 mesenchyme homeobox 2
MFN1 mitofusin 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR101-1 microRNA 101-1
MIR101-2 microRNA 101-2
MIR10B microRNA 10b
MIR125B1 microRNA 125b-1
MIR141 microRNA 141
MIR146A microRNA 146a
MIR17 microRNA 17
MIR191 microRNA 191
MIR193B microRNA 193b
MIR199A1 microRNA 199a-1
MIR199A2 microRNA 199a-2
MIR203A microRNA 203a
MIR205 microRNA 205
MIR21 microRNA 21
MIR217 microRNA 217
MIR22 microRNA 22
MIR23A microRNA 23a
MIR299 microRNA 299
MIR29A microRNA 29a
MIR30A microRNA 30a
MIR320C1 microRNA 320c-1
MIR34A microRNA 34a
MIR34B microRNA 34b
MIR34C microRNA 34c
MIR378A microRNA 378a
MIR449A microRNA 449a
MIR520C microRNA 520c
MIRLET7A1 microRNA let-7a-1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MORC3 MORC family CW-type zinc finger 3
MSN moesin
MTDH metadherin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXD1 MAX dimerization protein 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NAMPT nicotinamide phosphoribosyltransferase
NBN nibrin
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEK4 NIMA-related kinase 4
NEK6 NIMA-related kinase 6
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NINJ1 ninjurin 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NOX4 NADPH oxidase 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NTN4 netrin 4
OPA1 optic atrophy 1 (autosomal dominant)
PABPN1 poly(A) binding protein, nuclear 1
PARP1 poly (ADP-ribose) polymerase 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX3 paired box 3
PBRM1 polybromo 1
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PDGFB platelet-derived growth factor beta polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PEBP1 phosphatidylethanolamine binding protein 1
PGD phosphogluconate dehydrogenase
PGR progesterone receptor
PHB prohibitin
PIAS4 protein inhibitor of activated STAT, 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLAUR plasminogen activator, urokinase receptor
PLD2 phospholipase D2
PLK1 polo-like kinase 1
PML promyelocytic leukemia
PNPT1 polyribonucleotide nucleotidyltransferase 1
POSTN periostin, osteoblast specific factor
POT1 protection of telomeres 1
POU2F1 POU class 2 homeobox 1
POU4F1 POU class 4 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRL prolactin
PSEN1 presenilin 1
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
PTTG1 pituitary tumor-transforming 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAN RAN, member RAS oncogene family
RARB retinoic acid receptor, beta
RASEF RAS and EF-hand domain containing
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBBP8 retinoblastoma binding protein 8
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBM38 RNA binding motif protein 38
RBP2 retinol binding protein 2, cellular
RBX1 ring-box 1, E3 ubiquitin protein ligase
RECQL4 RecQ protein-like 4
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RIT1 Ras-like without CAAX 1
RNASET2 ribonuclease T2
RNF114 ring finger protein 114
ROMO1 reactive oxygen species modulator 1
RPL5 ribosomal protein L5
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RSL1D1 ribosomal L1 domain containing 1
RTN4 reticulon 4
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RXRB retinoid X receptor, beta
S100A6 S100 calcium binding protein A6
SATB1 SATB homeobox 1
SENP1 SUMO1/sentrin specific peptidase 1
SEPN1 selenoprotein N, 1
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHH sonic hedgehog
SIRT1 sirtuin 1
SIRT3 sirtuin 3
SIRT6 sirtuin 6
SIRT7 sirtuin 7
SKIL SKI-like proto-oncogene
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAI1 snail family zinc finger 1
SOD2 superoxide dismutase 2, mitochondrial
SORBS2 sorbin and SH3 domain containing 2
SOX5 SRY (sex determining region Y)-box 5
SP1 Sp1 transcription factor
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRSF1 serine/arginine-rich splicing factor 1
SRSF3 serine/arginine-rich splicing factor 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
SUN1 Sad1 and UNC84 domain containing 1
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TADA3 transcriptional adaptor 3
TAGLN transgelin
TBX2 T-box 2
TBX3 T-box 3
TCF3 transcription factor 3
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFB1 transforming growth factor, beta 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFB2 transforming growth factor, beta 2
TLR3 toll-like receptor 3
TNF tumor necrosis factor
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNS1 tensin 1
TOP1 topoisomerase (DNA) I
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TRA T cell receptor alpha locus
TSC22D1 TSC22 domain family, member 1
TSLP thymic stromal lymphopoietin
TWIST1 twist family bHLH transcription factor 1
TWIST2 twist family bHLH transcription factor 2
TXN thioredoxin
TXNIP thioredoxin interacting protein
TYMS thymidylate synthetase
UBE3A ubiquitin protein ligase E3A
UHRF1 ubiquitin-like with PHD and ring finger domains 1
VEGFA vascular endothelial growth factor A
WNT16 wingless-type MMTV integration site family, member 16
WNT5A wingless-type MMTV integration site family, member 5A
WRN Werner syndrome, RecQ helicase-like
WT1 Wilms tumor 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YBX1 Y box binding protein 1
YPEL3 yippee-like 3 (Drosophila)
YY1 YY1 transcription factor
ZBTB7A zinc finger and BTB domain containing 7A
ZMAT3 zinc finger, matrin-type 3
ZMPSTE24 zinc metallopeptidase STE24
ZMYND11 zinc finger, MYND-type containing 11
ZNF148 zinc finger protein 148