sepsis Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Systemic disease associated with the presence of pathogenic microorganisms or their toxins in the blood.|Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.|The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention.|Septicemia caused by pyogenic microorganisms (e.g., STAPHYLOCOCCUS; BACILLUS), resulting in the formation of secondary foci of SUPPURATION and multiple ABSCESSES.|A disease of infectious agent resulting from the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions. These pathogens are able to cause disease in animals and/or plants. Infectious pathologies are usually qualified as contagious disease (also called communicable disease) due to their potentiality of transmission from one person or species to another.|Sepsis associated with organ dysfunction distant from the site of infection. (Experimental Factor Ontology, EFO_0001420)
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Genes

27 genes associated with the disease sepsis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
BPI bactericidal/permeability-increasing protein
CARD11 caspase recruitment domain family, member 11
CD14 CD14 molecule
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
FGB fibrinogen beta chain
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA2 heat shock 70kDa protein 2
IFNG interferon, gamma
IL10 interleukin 10
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
LBP lipopolysaccharide binding protein
LTA lymphotoxin alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
NOD2 nucleotide-binding oligomerization domain containing 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
STARD3NL STARD3 N-terminal like
TLR1 toll-like receptor 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor