sepsis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Systemic disease associated with the presence of pathogenic microorganisms or their toxins in the blood.|Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.|The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention.|Septicemia caused by pyogenic microorganisms (e.g., STAPHYLOCOCCUS; BACILLUS), resulting in the formation of secondary foci of SUPPURATION and multiple ABSCESSES.|A disease of infectious agent resulting from the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions. These pathogens are able to cause disease in animals and/or plants. Infectious pathologies are usually qualified as contagious disease (also called communicable disease) due to their potentiality of transmission from one person or species to another.|Sepsis associated with organ dysfunction distant from the site of infection. (Experimental Factor Ontology, EFO_0001420)
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Genes

211 genes co-occuring with the biological term sepsis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACTA1 actin, alpha 1, skeletal muscle
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA2A adenosine A2a receptor
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
APLN apelin
APOC1 apolipoprotein C-I
AQP5 aquaporin 5
BCL2A1 BCL2-related protein A1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BID BH3 interacting domain death agonist
BPI bactericidal/permeability-increasing protein
BTLA B and T lymphocyte associated
C3 complement component 3
C5 complement component 5
C5AR1 complement component 5a receptor 1
C5AR2 complement component 5a receptor 2
CALCA calcitonin-related polypeptide alpha
CAMP cathelicidin antimicrobial peptide
CASP12 caspase 12 (gene/pseudogene)
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CD163 CD163 molecule
CD24 CD24 molecule
CD276 CD276 molecule
CD40LG CD40 ligand
CD5 CD5 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFH complement factor H
CHGA chromogranin A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIT1 chitinase 1 (chitotriosidase)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CST3 cystatin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH2 dimethylarginine dimethylaminohydrolase 2
DEFA1A3 defensin, alpha 1 and alpha 3, variable copy number locus
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DPP4 dipeptidyl-peptidase 4
EDN1 endothelin 1
ELANE elastase, neutrophil expressed
ELAVL1 ELAV like RNA binding protein 1
ESM1 endothelial cell-specific molecule 1
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FABP3 fatty acid binding protein 3, muscle and heart
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGB fibrinogen beta chain
FOS FBJ murine osteosarcoma viral oncogene homolog
GAS6 growth arrest-specific 6
GPR182 G protein-coupled receptor 182
GRPR gastrin-releasing peptide receptor
GSN gelsolin
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMK granzyme K (granzyme 3; tryptase II)
HAVCR2 hepatitis A virus cellular receptor 2
HMGB1 high mobility group box 1
HP haptoglobin
HSPA4 heat shock 70kDa protein 4
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL11 interleukin 11
IL12A interleukin 12A
IL12RB1 interleukin 12 receptor, beta 1
IL17A interleukin 17A
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL22 interleukin 22
IL27 interleukin 27
IL2RA interleukin 2 receptor, alpha
IL3 interleukin 3
IL32 interleukin 32
IL33R interleukin 33 receptor
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
IL7 interleukin 7
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK3 interleukin-1 receptor-associated kinase 3
IRG1 immunoresponsive 1 homolog (mouse)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUN jun proto-oncogene
KNG1 kininogen 1
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
LEP leptin
LTA lymphotoxin alpha
LTF lactotransferrin
LY96 lymphocyte antigen 96
MAPK14 mitogen-activated protein kinase 14
MARCO macrophage receptor with collagenous structure
MBL2 mannose-binding lectin (protein C) 2, soluble
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR122 microRNA 122
MIR143 microRNA 143
MIR146A microRNA 146a
MIR150 microRNA 150
MIR223 microRNA 223
MIR499A microRNA 499a
MIR574 microRNA 574
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MYD88 myeloid differentiation primary response 88
MYLK myosin light chain kinase
NAMPT nicotinamide phosphoribosyltransferase
ND1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PDCD1 programmed cell death 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PF4 platelet factor 4
PGF placental growth factor
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLG plasminogen
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRDX4 peroxiredoxin 4
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PTX3 pentraxin 3, long
PYGM phosphorylase, glycogen, muscle
RBP4 retinol binding protein 4, plasma
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCN1A sodium channel, voltage gated, type I alpha subunit
SDC1 syndecan 1
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFTPD surfactant protein D
SIRT1 sirtuin 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SST somatostatin
STIM1 stromal interaction molecule 1
SUFU suppressor of fused homolog (Drosophila)
TEK TEK tyrosine kinase, endothelial
TF transferrin
TFF1 trefoil factor 1
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
THBD thrombomodulin
TICAM1 toll-like receptor adaptor molecule 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP3 TNFAIP3 interacting protein 3
TNNI3 troponin I type 3 (cardiac)
TOLLIP toll interacting protein
TREM1 triggering receptor expressed on myeloid cells 1
TREM2 triggering receptor expressed on myeloid cells 2
TXN thioredoxin
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VIMP VCP-interacting membrane selenoprotein
VWF von Willebrand factor
WNT5A wingless-type MMTV integration site family, member 5A
XDH xanthine dehydrogenase
ZBTB7C zinc finger and BTB domain containing 7C