sepsis Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description Systemic disease associated with the presence of pathogenic microorganisms or their toxins in the blood.|Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.|The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention.|Septicemia caused by pyogenic microorganisms (e.g., STAPHYLOCOCCUS; BACILLUS), resulting in the formation of secondary foci of SUPPURATION and multiple ABSCESSES.|A disease of infectious agent resulting from the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions. These pathogens are able to cause disease in animals and/or plants. Infectious pathologies are usually qualified as contagious disease (also called communicable disease) due to their potentiality of transmission from one person or species to another.|Sepsis associated with organ dysfunction distant from the site of infection. (Experimental Factor Ontology, EFO_0001420)
External Link http://compbio.charite.de/hpoweb/showterm?id=HP:0100806
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Genes

50 genes associated with the sepsis phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACTG2 actin, gamma 2, smooth muscle, enteric
ADA adenosine deaminase
AK2 adenylate kinase 2
ALOX12B arachidonate 12-lipoxygenase, 12R type
APC adenomatous polyposis coli
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CHD7 chromodomain helicase DNA binding protein 7
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22
DCLRE1C DNA cross-link repair 1C
ECE1 endothelin converting enzyme 1
EDN3 endothelin 3
EDNRB endothelin receptor type B
ELANE elastase, neutrophil expressed
G6PC3 glucose 6 phosphatase, catalytic, 3
GALT galactose-1-phosphate uridylyltransferase
GDNF glial cell derived neurotrophic factor
HLA-B major histocompatibility complex, class I, B
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IL2RG interleukin 2 receptor, gamma
IL7R interleukin 7 receptor
ITGB4 integrin, beta 4
L1CAM L1 cell adhesion molecule
LIG4 ligase IV, DNA, ATP-dependent
LIPN lipase, family member N
LRRC8A leucine rich repeat containing 8 family, member A
MUT methylmalonyl CoA mutase
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NIPAL4 NIPA-like domain containing 4
NRTN neurturin
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEC plectin
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RET ret proto-oncogene
RMRP RNA component of mitochondrial RNA processing endoribonuclease
TCF3 transcription factor 3
TGM1 transglutaminase 1
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1