sepsis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Systemic disease associated with the presence of pathogenic microorganisms or their toxins in the blood.|Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.|The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention.|Septicemia caused by pyogenic microorganisms (e.g., STAPHYLOCOCCUS; BACILLUS), resulting in the formation of secondary foci of SUPPURATION and multiple ABSCESSES.|A disease of infectious agent resulting from the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions. These pathogens are able to cause disease in animals and/or plants. Infectious pathologies are usually qualified as contagious disease (also called communicable disease) due to their potentiality of transmission from one person or species to another.|Sepsis associated with organ dysfunction distant from the site of infection. (Experimental Factor Ontology, EFO_0001420)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005044
Similar Terms
Downloads & Tools

Genes

17 gene mutations causing the sepsis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCR breakpoint cluster region
BRCA2 breast cancer 2, early onset
CD36 CD36 molecule (thrombospondin receptor)
CFP complement factor properdin
CLCN3 chloride channel, voltage-sensitive 3
CTSC cathepsin C
CYBA cytochrome b-245, alpha polypeptide
FFAR2 free fatty acid receptor 2
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
MPO myeloperoxidase
MUC5B mucin 5B, oligomeric mucus/gel-forming
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SMTN smoothelin
SPI1 Spi-1 proto-oncogene