ser Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. (Gene Ontology, GO_0005790)
Similar Terms
Downloads & Tools

Genes

100 genes co-occuring with the biological term ser in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADGRE2 adhesion G protein-coupled receptor E2
ADSS adenylosuccinate synthase
AGER advanced glycosylation end product-specific receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
APP amyloid beta (A4) precursor protein
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
ATXN10 ataxin 10
AURKA aurora kinase A
AXIN1 axin 1
CDC25C cell division cycle 25C
CDK2 cyclin-dependent kinase 2
CDK9 cyclin-dependent kinase 9
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
COL1A1 collagen, type I, alpha 1
CRTC2 CREB regulated transcription coactivator 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DCTN1 dynactin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELAVL1 ELAV like RNA binding protein 1
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERRFI1 ERBB receptor feedback inhibitor 1
EZR ezrin
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F9 coagulation factor IX
FLNA filamin A, alpha
FOXO3 forkhead box O3
FXYD1 FXYD domain containing ion transport regulator 1
GLUD1 glutamate dehydrogenase 1
GP1BB glycoprotein Ib (platelet), beta polypeptide
GSK3B glycogen synthase kinase 3 beta
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HIRA histone cell cycle regulator
HIST1H3I histone cluster 1, H3i
HIST4H4 histone cluster 4, H4
ICAM1 intercellular adhesion molecule 1
IGF2 insulin-like growth factor 2
IGFBP6 insulin-like growth factor binding protein 6
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL1A interleukin 1, alpha
IL6 interleukin 6
IRS1 insulin receptor substrate 1
KLK6 kallikrein-related peptidase 6
LRRK2 leucine-rich repeat kinase 2
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MECP2 methyl CpG binding protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUTYH mutY homolog
NQO1 NAD(P)H dehydrogenase, quinone 1
OGG1 8-oxoguanine DNA glycosylase
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXN paxillin
RHAG Rh-associated glycoprotein
SASS6 spindle assembly 6 homolog (C. elegans)
SELE selectin E
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SMAD2 SMAD family member 2
SSH1 slingshot protein phosphatase 1
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYMPK symplekin
TCERG1 transcription elongation regulator 1
TF transferrin
THBS1 thrombospondin 1
TLR1 toll-like receptor 1
TLR6 toll-like receptor 6
TP53 tumor protein p53
TRPV4 transient receptor potential cation channel, subfamily V, member 4
UCMA upper zone of growth plate and cartilage matrix associated
ULK1 unc-51 like autophagy activating kinase 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VWF von Willebrand factor