ser Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. (Gene Ontology, GO_0005790)
Similar Terms
Downloads & Tools

Genes

326 proteins co-occuring with the biological term ser in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACACA acetyl-CoA carboxylase alpha
ACO1 aconitase 1, soluble
ADORA2A adenosine A2a receptor
ADRA2A adrenoceptor alpha 2A
AFAP1 actin filament associated protein 1
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANKRD6 ankyrin repeat domain 6
AQP2 aquaporin 2 (collecting duct)
AR androgen receptor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATF1 activating transcription factor 1
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
AXIN1 axin 1
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BECN1 beclin 1, autophagy related
BIK BCL2-interacting killer (apoptosis-inducing)
BMP15 bone morphogenetic protein 15
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
C1QBP complement component 1, q subcomponent binding protein
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASQ2 calsequestrin 2 (cardiac muscle)
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CD3G CD3g molecule, gamma (CD3-TCR complex)
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC37 cell division cycle 37
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK9 cyclin-dependent kinase 9
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFL1 cofilin 1 (non-muscle)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGB chorionic gonadotropin, beta polypeptide
CHEK2 checkpoint kinase 2
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHUK conserved helix-loop-helix ubiquitous kinase
COPS6 COP9 signalosome subunit 6
CPEB1 cytoplasmic polyadenylation element binding protein 1
CREB1 cAMP responsive element binding protein 1
CRHR1 corticotropin releasing hormone receptor 1
CRMP1 collapsin response mediator protein 1
CRTC2 CREB regulated transcription coactivator 2
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CRYAB crystallin, alpha B
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTPS1 CTP synthase 1
CTTN cortactin
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DAXX death-domain associated protein
DCP1A decapping mRNA 1A
DCTN1 dynactin 1
DCX doublecortin
DGKD diacylglycerol kinase, delta 130kDa
DMBT1 deleted in malignant brain tumors 1
DNM1 dynamin 1
DNM1L dynamin 1-like
DRD2 dopamine receptor D2
DROSHA drosha, ribonuclease type III
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
DUSP12 dual specificity phosphatase 12
DUSP8 dual specificity phosphatase 8
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF6 eukaryotic translation initiation factor 6
ELAVL1 ELAV like RNA binding protein 1
ELK1 ELK1, member of ETS oncogene family
EP300 E1A binding protein p300
ERRFI1 ERBB receptor feedback inhibitor 1
ESR1 estrogen receptor 1
ETV5 ets variant 5
ETV6 ets variant 6
F11R F11 receptor
FANCA Fanconi anemia, complementation group A
FBP1 fructose-1,6-bisphosphatase 1
FBXW5 F-box and WD repeat domain containing 5
FGA fibrinogen alpha chain
FLNA filamin A, alpha
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXG1 forkhead box G1
FOXO3 forkhead box O3
GAP43 growth associated protein 43
GAST gastrin
GJA1 gap junction protein, alpha 1, 43kDa
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GYS1 glycogen synthase 1 (muscle)
H2AFX H2A histone family, member X
HIST1H3A histone cluster 1, H3a
HIST1H4A histone cluster 1, H4a
HIST2H3C histone cluster 2, H3c
HMGB1 high mobility group box 1
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSF1 heat shock transcription factor 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPB8 heat shock 22kDa protein 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP6 insulin-like growth factor binding protein 6
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ING1 inhibitor of growth family, member 1
INSR insulin receptor
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KIF17 kinesin family member 17
KRT18 keratin 18, type I
KSR1 kinase suppressor of ras 1
L1CAM L1 cell adhesion molecule
LGALS3 lectin, galactoside-binding, soluble, 3
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LMTK1 lemur tail kinase 1
LRP6 low density lipoprotein receptor-related protein 6
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4 microtubule-associated protein 4
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MECP2 methyl CpG binding protein 2
MIP major intrinsic protein of lens fiber
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MPL MPL proto-oncogene, thrombopoietin receptor
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUTYH mutY homolog
MYBPC3 myosin binding protein C, cardiac
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
MYLK2 myosin light chain kinase 2
NBN nibrin
NCF1 neutrophil cytosolic factor 1
NDC80 NDC80 kinetochore complex component
NEK11 NIMA-related kinase 11
NF2 neurofibromin 2 (merlin)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFE2 nuclear factor, erythroid 2
NFE2L1 nuclear factor, erythroid 2-like 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC4 NLR family, CARD domain containing 4
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPR1 natriuretic peptide receptor 1
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRGN neurogranin (protein kinase C substrate, RC3)
NUMB numb homolog (Drosophila)
NUMBL numb homolog (Drosophila)-like
OPRD1 opioid receptor, delta 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PCBP1 poly(rC) binding protein 1
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PDX1 pancreatic and duodenal homeobox 1
PDZK1 PDZ domain containing 1
PER1 period circadian clock 1
PER2 period circadian clock 2
PFN1 profilin 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGR progesterone receptor
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PINK1 PTEN induced putative kinase 1
PKM pyruvate kinase, muscle
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAU plasminogen activator, urokinase
PLIN1 perilipin 1
PLK1 polo-like kinase 1
PNKP polynucleotide kinase 3'-phosphatase
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSIP1 PC4 and SFRS1 interacting protein 1
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRC protein tyrosine phosphatase, receptor type, C
PXN paxillin
PYGB phosphorylase, glycogen; brain
RAB11A RAB11A, member RAS oncogene family
RAD17 RAD17 homolog (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RANBP3 RAN binding protein 3
RARB retinoic acid receptor, beta
RB1 retinoblastoma 1
RCAN1 regulator of calcineurin 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGCC regulator of cell cycle
RHEB Ras homolog enriched in brain
RHO rhodopsin
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RUNX2 runt-related transcription factor 2
RYR1 ryanodine receptor 1 (skeletal)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCRIB scribbled planar cell polarity protein
SETD8 SET domain containing (lysine methyltransferase) 8
SFN stratifin
SGK2 serum/glucocorticoid regulated kinase 2
SGK3 serum/glucocorticoid regulated kinase family, member 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIK2 salt-inducible kinase 2
SIRT1 sirtuin 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD3 SMAD family member 3
SMC1A structural maintenance of chromosomes 1A
SNAP25 synaptosomal-associated protein, 25kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SSH1 slingshot protein phosphatase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STIM1 stromal interaction molecule 1
STMN1 stathmin 1
SYN1 synapsin I
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TARDBP TAR DNA binding protein
TBK1 TANK-binding kinase 1
TH tyrosine hydroxylase
TLN1 talin 1
TMPO thymopoietin
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNNI3 troponin I type 3 (cardiac)
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRAF3IP2 TRAF3 interacting protein 2
TRIM28 tripartite motif containing 28
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSKS testis-specific serine kinase substrate
TUBG1 tubulin, gamma 1
TWIST1 twist family bHLH transcription factor 1
TYMS thymidylate synthetase
VASP vasodilator-stimulated phosphoprotein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIM vimentin
WASF2 WAS protein family, member 2
WEE2 WEE1 homolog 2 (S. pombe)
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XPA xeroderma pigmentosum, complementation group A
YAP1 Yes-associated protein 1
ZBED3 zinc finger, BED-type containing 3