set Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description SET nuclear proto-oncogene|The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 6418)
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Genes

409 genes co-occuring with the biological term set in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACHE acetylcholinesterase (Yt blood group)
ACVRL1 activin A receptor type II-like 1
ADAM10 ADAM metallopeptidase domain 10
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADGRE5 adhesion G protein-coupled receptor E5
ADIPOR1 adiponectin receptor 1
ADRB2 adrenoceptor beta 2, surface
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGER advanced glycosylation end product-specific receptor
AGO2 argonaute RISC catalytic component 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AICDA activation-induced cytidine deaminase
AIRE autoimmune regulator
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALL1 Leukemia, acute lymphocytic, susceptibility to, 1
ALMS1 Alstrom syndrome protein 1
ALPP alkaline phosphatase, placental
ANPEP alanyl (membrane) aminopeptidase
AOC3 amine oxidase, copper containing 3
APC adenomatous polyposis coli
APIP APAF1 interacting protein
APOA1 apolipoprotein A-I
APOC1 apolipoprotein C-I
APOE apolipoprotein E
APOF apolipoprotein F
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARF4 ADP-ribosylation factor 4
ASCL1 achaete-scute family bHLH transcription factor 1
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATM ATM serine/threonine kinase
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP7B ATPase, Cu++ transporting, beta polypeptide
BAHD1 bromo adjacent homology domain containing 1
BBC3 BCL2 binding component 3
BCL2L1 BCL2-like 1
BIRC5 baculoviral IAP repeat containing 5
BRAP BRCA1 associated protein
BRCA1 breast cancer 1, early onset
BRI3 brain protein I3
CALB1 calbindin 1, 28kDa
CALB2 calbindin 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCNA1 cyclin A1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD1D CD1d molecule
CD4 CD4 molecule
CD6 CD6 molecule
CD8A CD8a molecule
CDH7 cadherin 7, type 2
CDK1 cyclin-dependent kinase 1
CDK11B cyclin-dependent kinase 11B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CFB complement factor B
CFL1 cofilin 1 (non-muscle)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHRM3 cholinergic receptor, muscarinic 3
CLCNKB chloride channel, voltage-sensitive Kb
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLOCK clock circadian regulator
CLU clusterin
CNGA3 cyclic nucleotide gated channel alpha 3
COMT catechol-O-methyltransferase
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREB3 cAMP responsive element binding protein 3
CREBBP CREB binding protein
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRP C-reactive protein, pentraxin-related
CSMD1 CUB and Sushi multiple domains 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CUL3 cullin 3
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DISC1 disrupted in schizophrenia 1
DPY19L2 dpy-19-like 2 (C. elegans)
DUSP5 dual specificity phosphatase 5
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DZIP3 DAZ interacting zinc finger protein 3
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F4 E2F transcription factor 4, p107/p130-binding
E2F6 E2F transcription factor 6
ECE2 endothelin converting enzyme 2
EGFLAM EGF-like, fibronectin type III and laminin G domains
EGFR epidermal growth factor receptor
EIF3F eukaryotic translation initiation factor 3, subunit F
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC2 excision repair cross-complementation group 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F10 coagulation factor X
F9 coagulation factor IX
FAM53B family with sequence similarity 53, member B
FBP1 fructose-1,6-bisphosphatase 1
FCRL3 Fc receptor-like 3
FEN1 flap structure-specific endonuclease 1
FGF1 fibroblast growth factor 1 (acidic)
FGF21 fibroblast growth factor 21
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXG1 forkhead box G1
FOXO1 forkhead box O1
FPGT fucose-1-phosphate guanylyltransferase
G6PC2 glucose-6-phosphatase, catalytic, 2
GAA glucosidase, alpha; acid
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GBA glucosidase, beta, acid
GJA1 gap junction protein, alpha 1, 43kDa
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GNRHR gonadotropin-releasing hormone receptor
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP1BB glycoprotein Ib (platelet), beta polypeptide
GP5 glycoprotein V (platelet)
GP9 glycoprotein IX (platelet)
GPC3 glypican 3
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRM7 glutamate receptor, metabotropic 7
GSTP1 glutathione S-transferase pi 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
H2AFY H2A histone family, member Y
HBB hemoglobin, beta
HCP5 HLA complex P5 (non-protein coding)
HELLS helicase, lymphoid-specific
HIRA histone cell cycle regulator
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB2 high mobility group box 2
HNRNPK heterogeneous nuclear ribonucleoprotein K
HOXB4 homeobox B4
HOXC9 homeobox C9
HPX hemopexin
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA7 heat shock 70kDa protein 7 (HSP70B)
HSPB1 heat shock 27kDa protein 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IDE insulin-degrading enzyme
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDS iduronate 2-sulfatase
IFNG interferon, gamma
IFNL1 interferon, lambda 1
IFNL3 interferon, lambda 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGLV@ immunoglobulin lambda variable cluster
IL12B interleukin 12B
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INS insulin
IQCB1 IQ motif containing B1
IRAK1 interleukin-1 receptor-associated kinase 1
IRF8 interferon regulatory factor 8
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUN jun proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNK18 potassium channel, two pore domain subfamily K, member 18
KDM1A lysine (K)-specific demethylase 1A
KDM2A lysine (K)-specific demethylase 2A
KDR kinase insert domain receptor
KIAA0556 KIAA0556
KIAA1524 KIAA1524
KIF2C kinesin family member 2C
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KISS1 KiSS-1 metastasis-suppressor
KLF5 Kruppel-like factor 5 (intestinal)
KMT2A lysine (K)-specific methyltransferase 2A
KMT2C lysine (K)-specific methyltransferase 2C
KMT2D lysine (K)-specific methyltransferase 2D
KMT2E lysine (K)-specific methyltransferase 2E
KRAS Kirsten rat sarcoma viral oncogene homolog
KRIT1 KRIT1, ankyrin repeat containing
LAT linker for activation of T cells
LCN1 lipocalin 1
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
LRRTM3 leucine rich repeat transmembrane neuronal 3
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAF1 MAF1 homolog (S. cerevisiae)
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAOA monoamine oxidase A
MAPK10 mitogen-activated protein kinase 10
MAPK14 mitogen-activated protein kinase 14
MCL1 myeloid cell leukemia 1
MCPH1 microcephalin 1
MEIS2 Meis homeobox 2
MET MET proto-oncogene, receptor tyrosine kinase
MICU1 mitochondrial calcium uptake 1
MIR106B microRNA 106b
MIR10A microRNA 10a
MIR146A microRNA 146a
MIR155 microRNA 155
MIR155HG MIR155 host gene
MIR17 microRNA 17
MIR199B microRNA 199b
MIR20A microRNA 20a
MIR34A microRNA 34a
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MSI2 musashi RNA-binding protein 2
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MT-ND6 NADH dehydrogenase, subunit 6 (complex I)
MT1X metallothionein 1X
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTRNR2L1 MT-RNR2-like 1
MTRNR2L10 MT-RNR2-like 10
MTRNR2L2 MT-RNR2-like 2
MTRNR2L3 MT-RNR2-like 3
MTRNR2L4 MT-RNR2-like 4
MTRNR2L5 MT-RNR2-like 5
MTRNR2L6 MT-RNR2-like 6
MTRNR2L7 MT-RNR2-like 7
MTRNR2L8 MT-RNR2-like 8
MTRNR2L9 MT-RNR2-like 9
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYD88 myeloid differentiation primary response 88
MYH14 myosin, heavy chain 14, non-muscle
MYO7A myosin VIIA
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NEUROD1 neuronal differentiation 1
NF2 neurofibromin 2 (merlin)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NMNAT1 nicotinamide nucleotide adenylyltransferase 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOTCH1 notch 1
NOTCH4 notch 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1I3 nuclear receptor subfamily 1, group I, member 3
NSD1 nuclear receptor binding SET domain protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUMA1 nuclear mitotic apparatus protein 1
OPRM1 opioid receptor, mu 1
OPTN optineurin
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PARP1 poly (ADP-ribose) polymerase 1
PAX3 paired box 3
PAX9 paired box 9
PCDH15 protocadherin-related 15
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDZK1 PDZ domain containing 1
PER2 period circadian clock 2
PEX19 peroxisomal biogenesis factor 19
PICALM phosphatidylinositol binding clathrin assembly protein
PKLR pyruvate kinase, liver and RBC
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLCG1 phospholipase C, gamma 1
PLSCR1 phospholipid scramblase 1
PPAP2A phosphatidic acid phosphatase type 2A
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PRDX2 peroxiredoxin 2
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTBP1 polypyrimidine tract binding protein 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTMA prothymosin, alpha
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RARB retinoic acid receptor, beta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBBP5 retinoblastoma binding protein 5
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRH retinal pigment epithelium-derived rhodopsin homolog
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A11 S100 calcium binding protein A11
SCN5A sodium channel, voltage gated, type V alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMG1 semenogelin I
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SET SET nuclear proto-oncogene
SETD7 SET domain containing (lysine methyltransferase) 7
SETD8 SET domain containing (lysine methyltransferase) 8
SETMAR SET domain and mariner transposase fusion gene
SFRP1 secreted frizzled-related protein 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SIM1 single-minded family bHLH transcription factor 1
SIM2 single-minded family bHLH transcription factor 2
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMYD2 SET and MYND domain containing 2
SMYD3 SET and MYND domain containing 3
SNAI1 snail family zinc finger 1
SOD1 superoxide dismutase 1, soluble
SOX17 SRY (sex determining region Y)-box 17
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SP7 Sp7 transcription factor
SPA17 sperm autoantigenic protein 17
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRA1 steroid receptor RNA activator 1
SRSF7 serine/arginine-rich splicing factor 7
SSB Sjogren syndrome antigen B (autoantigen La)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAAR1 trace amine associated receptor 1
TAAR2 trace amine associated receptor 2
TAAR3 trace amine associated receptor 3 (gene/pseudogene)
TAAR4P trace amine associated receptor 4, pseudogene
TAAR5 trace amine associated receptor 5
TAAR6 trace amine associated receptor 6
TAAR7P trace amine associated receptor 7, pseudogene
TAAR8 trace amine associated receptor 8
TAAR9 trace amine associated receptor 9 (gene/pseudogene)
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAL1 T-cell acute lymphocytic leukemia 1
TCERG1 transcription elongation regulator 1
TCF3 transcription factor 3
TCL1A T-cell leukemia/lymphoma 1A
THOC5 THO complex 5
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TMEM107 transmembrane protein 107
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TP63 tumor protein p63
TPP1 tripeptidyl peptidase I
TSHR thyroid stimulating hormone receptor
TTN titin
TTR transthyretin
UMOD uromodulin
UMPS uridine monophosphate synthetase
URI1 URI1, prefoldin-like chaperone
USB1 U6 snRNA biogenesis 1
USP9X ubiquitin specific peptidase 9, X-linked
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIM vimentin
VIP vasoactive intestinal peptide
VWF von Willebrand factor
WDR17 WD repeat domain 17
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WRNIP1 Werner helicase interacting protein 1
XBP1 X-box binding protein 1
XCL1 chemokine (C motif) ligand 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF217 zinc finger protein 217
ZNF804A zinc finger protein 804A