shc-grb2-sos complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. (Gene Ontology, GO_0070619)
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24 proteins co-occuring with the shc-grb2-sos complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
GRB2 growth factor receptor-bound protein 2 1.66115
DVL3 dishevelled segment polarity protein 3 0.876409
GRAP2 GRB2-related adaptor protein 2 0.723026
EIF3A eukaryotic translation initiation factor 3, subunit A 0.637578
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.625632
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.587199
BCR breakpoint cluster region 0.567585
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.565092
DVL1 dishevelled segment polarity protein 1 0.53454
ZHX2 zinc fingers and homeoboxes 2 0.499853
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.455214
EGFR epidermal growth factor receptor 0.431041
GHR growth hormone receptor 0.363185
HRAS Harvey rat sarcoma viral oncogene homolog 0.319702
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.302168
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.280716
RET ret proto-oncogene 0.26166
GRP gastrin-releasing peptide 0.235966
GDNF glial cell derived neurotrophic factor 0.217511
SYK spleen tyrosine kinase 0.190175
MAPK14 mitogen-activated protein kinase 14 0.185777
FYN FYN proto-oncogene, Src family tyrosine kinase 0.185777
CALD1 caldesmon 1 0.170629
TRH thyrotropin-releasing hormone 0.161484