siah1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description siah E3 ubiquitin protein ligase 1|This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6477)
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Genes

28 genes co-occuring with the biological term siah1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AFF1 AF4/FMR2 family, member 1
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CACYBP calcyclin binding protein
COPS5 COP9 signalosome subunit 5
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
E2F1 E2F transcription factor 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ELL2 elongation factor, RNA polymerase II, 2
FLT3 fms-related tyrosine kinase 3
GAPDH glyceraldehyde-3-phosphate dehydrogenase
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIPK2 homeodomain interacting protein kinase 2
KIF22 kinesin family member 22
KMT2A lysine (K)-specific methyltransferase 2A
MAP3K5 mitogen-activated protein kinase kinase kinase 5
PEG10 paternally expressed 10
PHC2 polyhomeotic homolog 2 (Drosophila)
PKD1 polycystic kidney disease 1 (autosomal dominant)
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
TLR4 toll-like receptor 4
TP53 tumor protein p53
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP19 ubiquitin specific peptidase 19