signal recognition particle, endoplasmic reticulum targeting Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. (Gene Ontology, GO_0005786)
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107 proteins co-occuring with the signal recognition particle, endoplasmic reticulum targeting cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SRP54 signal recognition particle 54kDa 2.31369
SRP19 signal recognition particle 19kDa 2.11876
SRP72 signal recognition particle 72kDa 1.91256
MMP8 matrix metallopeptidase 8 1.65212
SRP9 signal recognition particle 9kDa 1.56959
SRP9P1 signal recognition particle 9 pseudogene 1 1.56959
KPNA3 karyopherin alpha 3 (importin alpha 4) 1.45138
SRP68 signal recognition particle 68kDa 1.43726
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 1.42092
KPNA1 karyopherin alpha 1 (importin alpha 5) 1.29799
SRPR signal recognition particle receptor (docking protein) 1.13318
EVC Ellis van Creveld protein 1.05589
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 1.03428
KPNA5 karyopherin alpha 5 (importin alpha 6) 1.00399
PAPOLG poly(A) polymerase gamma 0.98488
PAAF1 proteasomal ATPase-associated factor 1 0.939742
EVC2 Ellis van Creveld syndrome 2 0.903673
DHRS7C dehydrogenase/reductase (SDR family) member 7C 0.894406
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 0.868586
IFT80 intraflagellar transport 80 0.86123
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.839646
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.777755
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.728389
NEK1 NIMA-related kinase 1 0.697784
CLK3 CDC-like kinase 3 0.692955
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.678108
TTC21B tetratricopeptide repeat domain 21B 0.671159
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.657326
WDR35 WD repeat domain 35 0.656033
NT5M 5',3'-nucleotidase, mitochondrial 0.65001
HSPB1 heat shock 27kDa protein 1 0.635868
TROVE2 TROVE domain family, member 2 0.632451
SOX21 SRY (sex determining region Y)-box 21 0.615437
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 0.611625
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.597697
IL1B interleukin 1, beta 0.593912
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 0.546472
TRIM24 tripartite motif containing 24 0.537005
DEFB103A defensin, beta 103A 0.535361
CRP C-reactive protein, pentraxin-related 0.533309
CERKL ceramide kinase-like 0.524704
AARS alanyl-tRNA synthetase 0.521023
SLPI secretory leukocyte peptidase inhibitor 0.517348
DEFB103B defensin, beta 103B 0.502693
LARP6 La ribonucleoprotein domain family, member 6 0.501881
TRIM21 tripartite motif containing 21 0.472011
UCN2 urocortin 2 0.468001
WRAP73 WD repeat containing, antisense to TP73 0.466399
MFRP membrane frizzled-related protein 0.457606
MOCS2 molybdenum cofactor synthesis 2 0.456012
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.448451
WDR19 WD repeat domain 19 0.442896
OSM oncostatin M 0.431041
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.413382
NDP Norrie disease (pseudoglioma) 0.41182
BTF3 basic transcription factor 3 0.407529
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.400527
SRA1 steroid receptor RNA activator 1 0.39471
MKKS McKusick-Kaufman syndrome 0.392388
SRSF9 serine/arginine-rich splicing factor 9 0.386208
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.383124
MMP1 matrix metallopeptidase 1 0.376202
CYB5A cytochrome b5 type A (microsomal) 0.355183
CRYAB crystallin, alpha B 0.355183
CRHR1 corticotropin releasing hormone receptor 1 0.342664
SRSF5 serine/arginine-rich splicing factor 5 0.337751
STX2 syntaxin 2 0.336996
SEMG1 semenogelin I 0.334733
IL17A interleukin 17A 0.332472
HARS histidyl-tRNA synthetase 0.329084
PRSS21 protease, serine, 21 (testisin) 0.321575
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.320826
CXCL8 chemokine (C-X-C motif) ligand 8 0.311478
DCPS decapping enzyme, scavenger 0.307377
SEC62 SEC62 homolog (S. cerevisiae) 0.300682
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.287352
TNF tumor necrosis factor 0.281085
INVS inversin 0.2708
CRHR2 corticotropin releasing hormone receptor 2 0.266408
MANF mesencephalic astrocyte-derived neurotrophic factor 0.250389
SRSF3 serine/arginine-rich splicing factor 3 0.249302
RPS15 ribosomal protein S15 0.247854
IBSP integrin-binding sialoprotein 0.235966
RPS5 ribosomal protein S5 0.235249
PAPD7 PAP associated domain containing 7 0.224558
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.215761
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.215412
LBP lipopolysaccharide binding protein 0.209858
TGM4 transglutaminase 4 0.203699
LIFR leukemia inhibitory factor receptor alpha 0.19601
SNAPIN SNAP-associated protein 0.195025
RPN1 ribophorin I 0.193394
EIF5A eukaryotic translation initiation factor 5A 0.191456
IFT122 intraflagellar transport 122 0.184547
RAB40AL RAB40A, member RAS oncogene family-like 0.183328
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.180045
RHCE Rh blood group, CcEe antigens 0.178877
SPP1 secreted phosphoprotein 1 0.175466
FDXR ferredoxin reductase 0.172468
HOXA9 homeobox A9 0.171937
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 0.16935
TIMP1 TIMP metallopeptidase inhibitor 1 0.166884
STX1A syntaxin 1A (brain) 0.166167
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.158882
PLAT plasminogen activator, tissue 0.157578
TPP1 tripeptidyl peptidase I 0.156863
STC1 stanniocalcin 1 0.156688