The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway. (Gene Ontology, GO_0007227)
1 genes participating in the signal transduction downstream of smoothened biological process from the curated GO Biological Process Annotations 2015 dataset.
