signalosome Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. (Gene Ontology, GO_0008180)
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Genes

57 genes co-occuring with the biological term signalosome in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADRA1D adrenoceptor alpha 1D
APC adenomatous polyposis coli
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARRB1 arrestin, beta 1
BCAR1 breast cancer anti-estrogen resistance 1
BCL10 B-cell CLL/lymphoma 10
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CAND1 cullin-associated and neddylation-dissociated 1
CARD11 caspase recruitment domain family, member 11
CDC34 cell division cycle 34
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHUK conserved helix-loop-helix ubiquitous kinase
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COPS2 COP9 signalosome subunit 2
COPS4 COP9 signalosome subunit 4
COPS5 COP9 signalosome subunit 5
COPS8 COP9 signalosome subunit 8
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
DTNA dystrobrevin, alpha
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF3E eukaryotic translation initiation factor 3, subunit E
GPS1 G protein pathway suppressor 1
KSR1 kinase suppressor of ras 1
LSP1 lymphocyte-specific protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MALT1 MALT1 paracaspase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MAVS mitochondrial antiviral signaling protein
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOTCH1 notch 1
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCD protein kinase C, delta
PRKD1 protein kinase D1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RXFP1 relaxin/insulin-like family peptide receptor 1
SENP8 SUMO/sentrin specific peptidase family member 8
SKP1 S-phase kinase-associated protein 1
SYK spleen tyrosine kinase
THBS1 thrombospondin 1
THEMIS thymocyte selection associated
TOR1A torsin family 1, member A (torsin A)
USP15 ubiquitin specific peptidase 15
UXT ubiquitously-expressed, prefoldin-like chaperone
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta