simvastatin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. (Chemical Entities of Biological Interest Ontology, CHEBI_9150)
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Genes

57 genes co-occuring with the biological term simvastatin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
AGTR1 angiotensin II receptor, type 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BGLAP bone gamma-carboxyglutamate (gla) protein
CCL2 chemokine (C-C motif) ligand 2
CD40LG CD40 ligand
CFH complement factor H
COL1A1 collagen, type I, alpha 1
CRP C-reactive protein, pentraxin-related
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DHCR24 24-dehydrocholesterol reductase
DMP1 dentin matrix acidic phosphoprotein 1
EAF2 ELL associated factor 2
EDN1 endothelin 1
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FADS1 fatty acid desaturase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
IL1B interleukin 1, beta
IL6 interleukin 6
KLF1 Kruppel-like factor 1 (erythroid)
KLF2 Kruppel-like factor 2
LDLR low density lipoprotein receptor
LPA lipoprotein, Lp(a)
MAPK1 mitogen-activated protein kinase 1
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS3 nitric oxide synthase 3 (endothelial cell)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAUR plasminogen activator, urokinase receptor
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
RBP4 retinol binding protein 4, plasma
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TSC2 tuberous sclerosis 2
VCAM1 vascular cell adhesion molecule 1
VWF von Willebrand factor
WT1 Wilms tumor 1