sirolimus-1667 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the sirolimus-1667 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AHNAK2 AHNAK nucleoprotein 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD12 ankyrin repeat domain 12
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASIC1 acid sensing (proton gated) ion channel 1
ATXN3 ataxin 3
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF93 chromosome 14 open reading frame 93
CACFD1 calcium channel flower domain containing 1
CCNG2 cyclin G2
CEMIP cell migration inducing protein, hyaluronan binding
CEP162 centrosomal protein 162kDa
CHKB choline kinase beta
CHRM3 cholinergic receptor, muscarinic 3
COL1A1 collagen, type I, alpha 1
CPT2 carnitine palmitoyltransferase 2
CTH cystathionine gamma-lyase
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
FLCN folliculin
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GREB1 growth regulation by estrogen in breast cancer 1
HDAC5 histone deacetylase 5
HIST1H2AI histone cluster 1, H2ai
HMOX1 heme oxygenase 1
HOXB7 homeobox B7
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFT27 intraflagellar transport 27
ING4 inhibitor of growth family, member 4
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IPO9 importin 9
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KIAA0485 uncharacterized LOC57235
KIFAP3 kinesin-associated protein 3
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC644450 uncharacterized LOC644450
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED20 mediator complex subunit 20
MTAP methylthioadenosine phosphorylase
MUC3A mucin 3A, cell surface associated
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NIPAL2 NIPA-like domain containing 2
NMT2 N-myristoyltransferase 2
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PAPPA2 pappalysin 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLSCR1 phospholipid scramblase 1
POU2F2 POU class 2 homeobox 2
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPOX protoporphyrinogen oxidase
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRLR prolactin receptor
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTCH1 patched 1
PTK6 protein tyrosine kinase 6
RBL2 retinoblastoma-like 2
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RECQL5 RecQ protein-like 5
RNMT RNA (guanine-7-) methyltransferase
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRAGD Ras-related GTP binding D
RTN2 reticulon 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEC24A SEC24 family member A
SECISBP2 SECIS binding protein 2
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIGLEC15 sialic acid binding Ig-like lectin 15
SIK1 salt-inducible kinase 1
SLC41A3 solute carrier family 41, member 3
SMAD3 SMAD family member 3
STON1 stonin 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM259 transmembrane protein 259
TREX1 three prime repair exonuclease 1
TRIM2 tripartite motif containing 2
TRIM45 tripartite motif containing 45
TRIM66 tripartite motif containing 66
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TXNIP thioredoxin interacting protein
YIPF4 Yip1 domain family, member 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF226 zinc finger protein 226
ZNF45 zinc finger protein 45
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ADGRA3 adhesion G protein-coupled receptor A3
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASPHD1 aspartate beta-hydroxylase domain containing 1
AVPI1 arginine vasopressin-induced 1
C1ORF159 chromosome 1 open reading frame 159
C6ORF47 chromosome 6 open reading frame 47
C7ORF43 chromosome 7 open reading frame 43
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX4 chromobox homolog 4
CCDC9 coiled-coil domain containing 9
CEP72 centrosomal protein 72kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHPF chondroitin polymerizing factor
CIC capicua transcriptional repressor
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLSPN claspin
CORO1A coronin, actin binding protein, 1A
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DPH2 DPH2 homolog (S. cerevisiae)
DUSP13 dual specificity phosphatase 13
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5A2 eukaryotic translation initiation factor 5A2
ERN2 endoplasmic reticulum to nucleus signaling 2
FKBP14 FK506 binding protein 14, 22 kDa
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GATA4 GATA binding protein 4
GID4 GID complex subunit 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GMIP GEM interacting protein
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRWD1 glutamate-rich WD repeat containing 1
H2AFY2 H2A histone family, member Y2
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
INPP5J inositol polyphosphate-5-phosphatase J
INPPL1 inositol polyphosphate phosphatase-like 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KLK5 kallikrein-related peptidase 5
LIG4 ligase IV, DNA, ATP-dependent
LIME1 Lck interacting transmembrane adaptor 1
LMNB1 lamin B1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LUC7L LUC7-like (S. cerevisiae)
MAK16 MAK16 homolog (S. cerevisiae)
MAP7D1 MAP7 domain containing 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCC mutated in colorectal cancers
MED15 mediator complex subunit 15
MFSD11 major facilitator superfamily domain containing 11
MICALL2 MICAL-like 2
MIR22HG MIR22 host gene
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MUM1 melanoma associated antigen (mutated) 1
NOP2 NOP2 nucleolar protein
PARD6A par-6 family cell polarity regulator alpha
PARG poly (ADP-ribose) glycohydrolase
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PMCH pro-melanin-concentrating hormone
PODXL2 podocalyxin-like 2
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPP6R3 protein phosphatase 6, regulatory subunit 3
PUS1 pseudouridylate synthase 1
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RAI14 retinoic acid induced 14
RECQL4 RecQ protein-like 4
RGS16 regulator of G-protein signaling 16
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SETD1A SET domain containing 1A
SETD8 SET domain containing (lysine methyltransferase) 8
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TBCC tubulin folding cofactor C
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM104 transmembrane protein 104
TMEM51 transmembrane protein 51
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
WDR91 WD repeat domain 91
YARS tyrosyl-tRNA synthetase
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial