sirolimus-5204 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the sirolimus-5204 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ADCK3 aarF domain containing kinase 3
AHCYL2 adenosylhomocysteinase-like 2
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALOXE3 arachidonate lipoxygenase 3
AMH anti-Mullerian hormone
AMT aminomethyltransferase
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
APOM apolipoprotein M
ARTN artemin
ATAT1 alpha tubulin acetyltransferase 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAPN9 calpain 9
CBX7 chromobox homolog 7
CCNG2 cyclin G2
CLCN7 chloride channel, voltage-sensitive 7
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL1A1 collagen, type I, alpha 1
CTBS chitobiase, di-N-acetyl-
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
EFCAB2 EF-hand calcium binding domain 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX2 epoxide hydrolase 2, cytoplasmic
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FHIT fragile histidine triad
FLJ22184
GABARAPL1 GABA(A) receptor-associated protein like 1
GFI1 growth factor independent 1 transcription repressor
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GPER1 G protein-coupled estrogen receptor 1
GPR143 G protein-coupled receptor 143
HAMP hepcidin antimicrobial peptide
HEG1 heart development protein with EGF-like domains 1
HR hair growth associated
HSPB11 heat shock protein family B (small), member 11
IFT27 intraflagellar transport 27
IGFBP3 insulin-like growth factor binding protein 3
ING4 inhibitor of growth family, member 4
IRS2 insulin receptor substrate 2
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KIAA1456 KIAA1456
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K8 mitogen-activated protein kinase kinase kinase 8
METTL7A methyltransferase like 7A
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MPPE1 metallophosphoesterase 1
MTCP1 mature T-cell proliferation 1
MXD4 MAX dimerization protein 4
MZF1 myeloid zinc finger 1
N4BP3 NEDD4 binding protein 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLK3 polo-like kinase 3
PVT1 Pvt1 oncogene (non-protein coding)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD52 RAD52 homolog (S. cerevisiae)
RALGDS ral guanine nucleotide dissociation stimulator
RBL2 retinoblastoma-like 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RIMS3 regulating synaptic membrane exocytosis 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SDC3 syndecan 3
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC35E2 solute carrier family 35, member E2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMIM14 small integral membrane protein 14
SNX13 sorting nexin 13
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRCAP Snf2-related CREBBP activator protein
STARD3 StAR-related lipid transfer (START) domain containing 3
TACC1 transforming, acidic coiled-coil containing protein 1
TECTA tectorin alpha
TMCO6 transmembrane and coiled-coil domains 6
TRAK1 trafficking protein, kinesin binding 1
TTC9 tetratricopeptide repeat domain 9
TUBA4B tubulin, alpha 4b
TXNIP thioredoxin interacting protein
ULK2 unc-51 like autophagy activating kinase 2
UROD uroporphyrinogen decarboxylase
VPS9D1 VPS9 domain containing 1
YY2 YY2 transcription factor
ZNF350 zinc finger protein 350
ZNF532 zinc finger protein 532
ZNF862 zinc finger protein 862
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
AFF4 AF4/FMR2 family, member 4
AKIRIN1 akirin 1
ARMC6 armadillo repeat containing 6
BAHCC1 BAH domain and coiled-coil containing 1
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
BYSL bystin-like
C7ORF43 chromosome 7 open reading frame 43
CBX8 chromobox homolog 8
CCDC86 coiled-coil domain containing 86
CCDC88C coiled-coil domain containing 88C
CCNO cyclin O
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP6 charged multivesicular body protein 6
CHMP7 charged multivesicular body protein 7
CORO1A coronin, actin binding protein, 1A
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCP1A decapping mRNA 1A
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDIT3 DNA-damage-inducible transcript 3
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DUSP8 dual specificity phosphatase 8
DVL1 dishevelled segment polarity protein 1
EAF2 ELL associated factor 2
ERCC5 excision repair cross-complementation group 5
FAAH fatty acid amide hydrolase
FKBP10 FK506 binding protein 10, 65 kDa
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALE UDP-galactose-4-epimerase
GALK1 galactokinase 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HCFC2 host cell factor C2
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFRD1 interferon-related developmental regulator 1
IL22 interleukin 22
INPPL1 inositol polyphosphate phosphatase-like 1
IRF9 interferon regulatory factor 9
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
METTL16 methyltransferase like 16
MLYCD malonyl-CoA decarboxylase
MRPL52 mitochondrial ribosomal protein L52
MSX1 msh homeobox 1
MUC3A mucin 3A, cell surface associated
NARFL nuclear prelamin A recognition factor-like
NCS1 neuronal calcium sensor 1
NOL12 nucleolar protein 12
NRSN2 neurensin 2
NSD1 nuclear receptor binding SET domain protein 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PCDHA6 protocadherin alpha 6
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRR14L proline rich 14-like
PRR4 proline rich 4 (lacrimal)
PTDSS2 phosphatidylserine synthase 2
RAI14 retinoic acid induced 14
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGS16 regulator of G-protein signaling 16
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF43 ring finger protein 43
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOX12 SRY (sex determining region Y)-box 12
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SURF2 surfeit 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TMEM39B transmembrane protein 39B
TMEM53 transmembrane protein 53
TNS2 tensin 2
TRABD TraB domain containing
TRIM25 tripartite motif containing 25
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TWISTNB TWIST neighbor
UNC119 unc-119 homolog (C. elegans)
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VGF VGF nerve growth factor inducible
WDR4 WD repeat domain 4
WDR43 WD repeat domain 43
YEATS2 YEATS domain containing 2
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZNF205 zinc finger protein 205
ZNF446 zinc finger protein 446
ZNF696 zinc finger protein 696