sirolimus-6201 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
Similar Terms
Downloads & Tools

Genes

195 genes differentially expressed following the sirolimus-6201 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ADCY9 adenylate cyclase 9
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARR3 arrestin 3, retinal (X-arrestin)
BCL2 B-cell CLL/lymphoma 2
BIN1 bridging integrator 1
C3ORF52 chromosome 3 open reading frame 52
C5ORF45 chromosome 5 open reading frame 45
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CD300A CD300a molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CDON cell adhesion associated, oncogene regulated
CNTN5 contactin 5
COPE coatomer protein complex, subunit epsilon
CST4 cystatin S
CXCL3 chemokine (C-X-C motif) ligand 3
CYB5R2 cytochrome b5 reductase 2
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
ELL2 elongation factor, RNA polymerase II, 2
EMID1 EMI domain containing 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FADS3 fatty acid desaturase 3
FCAR Fc fragment of IgA receptor
FGFR1 fibroblast growth factor receptor 1
FOXF1 forkhead box F1
FST follistatin
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GDF2 growth differentiation factor 2
GLI3 GLI family zinc finger 3
GNRHR gonadotropin-releasing hormone receptor
GPR3 G protein-coupled receptor 3
GRIK1 glutamate receptor, ionotropic, kainate 1
HAB1 B1 for mucin
HIST1H2AJ histone cluster 1, H2aj
HMOX1 heme oxygenase 1
HNF1B HNF1 homeobox B
HOXA4 homeobox A4
IFNA4 interferon, alpha 4
IGHA1 immunoglobulin heavy constant alpha 1
IGL immunoglobulin lambda locus
IL10 interleukin 10
INHBA inhibin, beta A
IRF4 interferon regulatory factor 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KLHL25 kelch-like family member 25
LHFPL2 lipoma HMGIC fusion partner-like 2
LPAR1 lysophosphatidic acid receptor 1
MARC2 mitochondrial amidoxime reducing component 2
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MED25 mediator complex subunit 25
MPZL2 myelin protein zero-like 2
MSI1 musashi RNA-binding protein 1
MSR1 macrophage scavenger receptor 1
MT1G metallothionein 1G
MUC3A mucin 3A, cell surface associated
NIPAL2 NIPA-like domain containing 2
OCA2 oculocutaneous albinism II
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCDHGA1 protocadherin gamma subfamily A, 1
PDE4D phosphodiesterase 4D, cAMP-specific
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDLIM4 PDZ and LIM domain 4
PLD2 phospholipase D2
PLXNB2 plexin B2
PRLR prolactin receptor
PRSS50 protease, serine, 50
PTMS parathymosin
RARA retinoic acid receptor, alpha
SCN10A sodium channel, voltage gated, type X alpha subunit
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLIT1 slit homolog 1 (Drosophila)
SPDEF SAM pointed domain containing ETS transcription factor
SSTR5 somatostatin receptor 5
STX2 syntaxin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB3 transforming growth factor, beta 3
TIMELESS timeless circadian clock
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TK2 thymidine kinase 2, mitochondrial
TM4SF5 transmembrane 4 L six family member 5
TMEM63A transmembrane protein 63A
TMPRSS11D transmembrane protease, serine 11D
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UPP1 uridine phosphorylase 1
USP27X ubiquitin specific peptidase 27, X-linked
YIPF2 Yip1 domain family, member 2
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADGRE1 adhesion G protein-coupled receptor E1
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARSB arylsulfatase B
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BATF3 basic leucine zipper transcription factor, ATF-like 3
C11ORF71 chromosome 11 open reading frame 71
C17ORF80 chromosome 17 open reading frame 80
C17ORF85 chromosome 17 open reading frame 85
CCNJ cyclin J
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTH cystathionine gamma-lyase
CTSG cathepsin G
CUL9 cullin 9
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CXCR2 chemokine (C-X-C motif) receptor 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC6L excision repair cross-complementation group 6-like
EXD3 exonuclease 3'-5' domain containing 3
FAM184A family with sequence similarity 184, member A
FAM86B1 family with sequence similarity 86, member B1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FURIN furin (paired basic amino acid cleaving enzyme)
GALK1 galactokinase 1
GCH1 GTP cyclohydrolase 1
GIPC1 GIPC PDZ domain containing family, member 1
GLCE glucuronic acid epimerase
GPS1 G protein pathway suppressor 1
GSTA4 glutathione S-transferase alpha 4
HHLA3 HERV-H LTR-associating 3
HIRA histone cell cycle regulator
HIST1H1B histone cluster 1, H1b
HIST2H2AA3 histone cluster 2, H2aa3
HYAL3 hyaluronoglucosaminidase 3
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KIAA1024 KIAA1024
KIF17 kinesin family member 17
KIF1B kinesin family member 1B
LAMB3 laminin, beta 3
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIN7B lin-7 homolog B (C. elegans)
LOC100286895 cell division cycle 27 homolog pseudogene
LOC157562 uncharacterized LOC157562
MEFV Mediterranean fever
METTL2B methyltransferase like 2B
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MPZ myelin protein zero
MTMR12 myotubularin related protein 12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NCAPH non-SMC condensin I complex, subunit H
NDE1 nudE neurodevelopment protein 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NPFFR1 neuropeptide FF receptor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H3 nuclear receptor subfamily 1, group H, member 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PARP16 poly (ADP-ribose) polymerase family, member 16
PDE12 phosphodiesterase 12
PHACTR1 phosphatase and actin regulator 1
PHGDH phosphoglycerate dehydrogenase
PMCH pro-melanin-concentrating hormone
POMZP3 POM121 and ZP3 fusion
PPIEL peptidylprolyl isomerase E-like pseudogene
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PSAT1 phosphoserine aminotransferase 1
PYGB phosphorylase, glycogen; brain
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMYD5 SMYD family member 5
SPATA20 spermatogenesis associated 20
STAT5A signal transducer and activator of transcription 5A
THRAP3 thyroid hormone receptor associated protein 3
TMEM254 transmembrane protein 254
TMEM62 transmembrane protein 62
TSPYL2 TSPY-like 2
TXLNG taxilin gamma
UNKL unkempt family zinc finger-like
VLDLR very low density lipoprotein receptor
XAB2 XPA binding protein 2
YY2 YY2 transcription factor
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF225 zinc finger protein 225
ZNF354A zinc finger protein 354A
ZNF696 zinc finger protein 696
ZNF76 zinc finger protein 76