sirolimus-7001 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the sirolimus-7001 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
AGGF1 angiogenic factor with G patch and FHA domains 1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALMS1 Alstrom syndrome protein 1
ALS2CL ALS2 C-terminal like
BCAS1 breast carcinoma amplified sequence 1
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTD biotinidase
C14ORF93 chromosome 14 open reading frame 93
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CHST10 carbohydrate sulfotransferase 10
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL9A2 collagen, type IX, alpha 2
CSNK1E casein kinase 1, epsilon
CSPP1 centrosome and spindle pole associated protein 1
CTH cystathionine gamma-lyase
DBN1 drebrin 1
DESI2 desumoylating isopeptidase 2
DMPK dystrophia myotonica-protein kinase
DNAAF1 dynein, axonemal, assembly factor 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FBRS fibrosin
FRZB frizzled-related protein
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GRAMD1C GRAM domain containing 1C
GSAP gamma-secretase activating protein
HEMK1 HemK methyltransferase family member 1
HFE hemochromatosis
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IFT38 intraflagellar transport 38
INADL InaD-like (Drosophila)
IQSEC2 IQ motif and Sec7 domain 2
JAG1 jagged 1
JRK Jrk homolog (mouse)
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA0430 KIAA0430
KIF13B kinesin family member 13B
KLHL24 kelch-like family member 24
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMB3 laminin, beta 3
LEPR leptin receptor
LOC647070 uncharacterized LOC647070
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPT microtubule-associated protein tau
MB myoglobin
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUC1 mucin 1, cell surface associated
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYO9B myosin IXB
NAV2 neuron navigator 2
NEURL1 neuralized E3 ubiquitin protein ligase 1
NLRX1 NLR family member X1
OLFM1 olfactomedin 1
PAQR6 progestin and adipoQ receptor family member VI
PARP16 poly (ADP-ribose) polymerase family, member 16
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4DIP phosphodiesterase 4D interacting protein
PLSCR1 phospholipid scramblase 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKX protein kinase, X-linked
PRUNE2 prune homolog 2 (Drosophila)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PVT1 Pvt1 oncogene (non-protein coding)
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RNF39 ring finger protein 39
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RTN2 reticulon 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3BP2 SH3-domain binding protein 2
SIDT2 SID1 transmembrane family, member 2
SIK1 salt-inducible kinase 1
SIVA1 SIVA1, apoptosis-inducing factor
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SMIM14 small integral membrane protein 14
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SSH1 slingshot protein phosphatase 1
SYNJ2 synaptojanin 2
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNRC6B trinucleotide repeat containing 6B
TOR4A torsin family 4, member A
TREX1 three prime repair exonuclease 1
TRIM66 tripartite motif containing 66
TTLL3 tubulin tyrosine ligase-like family member 3
TXNIP thioredoxin interacting protein
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
ZBTB48 zinc finger and BTB domain containing 48
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM6 zinc finger, MYM-type 6
ZNF446 zinc finger protein 446
ZNF571 zinc finger protein 571
ZNF74 zinc finger protein 74
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASAP1-IT1 ASAP1 intronic transcript 1
ATAD2B ATPase family, AAA domain containing 2B
ATAD3A ATPase family, AAA domain containing 3A
AXIN1 axin 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAG4 BCL2-associated athanogene 4
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCOR BCL6 corepressor
BCORL1 BCL6 corepressor-like 1
BMP4 bone morphogenetic protein 4
CAPRIN2 caprin family member 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCDC86 coiled-coil domain containing 86
CDK3 cyclin-dependent kinase 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLCN2 chloride channel, voltage-sensitive 2
CORO1A coronin, actin binding protein, 1A
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EAF2 ELL associated factor 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EML4 echinoderm microtubule associated protein like 4
FA2H fatty acid 2-hydroxylase
FGD6 FYVE, RhoGEF and PH domain containing 6
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
GALT galactose-1-phosphate uridylyltransferase
GPATCH2L G patch domain containing 2-like
GPX2 glutathione peroxidase 2
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H2BJ histone cluster 1, H2bj
IFRD1 interferon-related developmental regulator 1
INTS9 integrator complex subunit 9
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JMJD4 jumonji domain containing 4
KCTD20 potassium channel tetramerization domain containing 20
KLC2 kinesin light chain 2
LOC100287590 uncharacterized LOC100287590
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC8E leucine rich repeat containing 8 family, member E
LZTR1 leucine-zipper-like transcription regulator 1
MAP7D1 MAP7 domain containing 1
MAPK12 mitogen-activated protein kinase 12
METTL2B methyltransferase like 2B
MSL1 male-specific lethal 1 homolog (Drosophila)
MTERF4 mitochondrial transcription termination factor 4
MYO1E myosin IE
NDE1 nudE neurodevelopment protein 1
OTUD3 OTU deubiquitinase 3
PACS1 phosphofurin acidic cluster sorting protein 1
PARP12 poly (ADP-ribose) polymerase family, member 12
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PYCRL pyrroline-5-carboxylate reductase-like
PYGB phosphorylase, glycogen; brain
RAB3D RAB3D, member RAS oncogene family
RAI14 retinoic acid induced 14
RBM41 RNA binding motif protein 41
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS17 regulator of G-protein signaling 17
RIBC2 RIB43A domain with coiled-coils 2
RNF126P1 ring finger protein 126 pseudogene 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SH2D4A SH2 domain containing 4A
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK4 serine peptidase inhibitor, Kazal type 4
STBD1 starch binding domain 1
STK25 serine/threonine kinase 25
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TBC1D17 TBC1 domain family, member 17
TGDS TDP-glucose 4,6-dehydratase
TMEM180 transmembrane protein 180
TRABD TraB domain containing
TRAF5 TNF receptor-associated factor 5
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTC30A tetratricopeptide repeat domain 30A
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP20 ubiquitin specific peptidase 20
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VEGFC vascular endothelial growth factor C
ZNF134 zinc finger protein 134
ZNF280D zinc finger protein 280D
ZNF324 zinc finger protein 324
ZNF787 zinc finger protein 787