sirt1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description sirtuin 1|This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] (NCBI Entrez Gene Database, 23411)
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Genes

188 genes co-occuring with the biological term sirt1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE2 angiotensin I converting enzyme 2
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
AR androgen receptor
ATF4 activating transcription factor 4
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCLAF1 BCL2-associated transcription factor 1
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAT catalase
CBX8 chromobox homolog 8
CCAR2 cell cycle and apoptosis regulator 2
CCND1 cyclin D1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK2 checkpoint kinase 2
CLDN1 claudin 1
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CREBZF CREB/ATF bZIP transcription factor
CRNN cornulin
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTTN cortactin
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
EIF2A eukaryotic translation initiation factor 2A, 65kDa
ELAVL1 ELAV like RNA binding protein 1
ELAVL4 ELAV like neuron-specific RNA binding protein 4
ENHO energy homeostasis associated
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ESRRG estrogen-related receptor gamma
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FOXA2 forkhead box A2
FOXL2 forkhead box L2
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXP3 forkhead box P3
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GATA4 GATA binding protein 4
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HDAC4 histone deacetylase 4
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HNF1A HNF1 homeobox A
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
IL17A interleukin 17A
IL1B interleukin 1, beta
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IRS2 insulin receptor substrate 2
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
KAT8 K(lysine) acetyltransferase 8
KSR1 kinase suppressor of ras 1
MAOA monoamine oxidase A
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAT2B methionine adenosyltransferase II, beta
MAX MYC associated factor X
MCC mutated in colorectal cancers
MCM10 minichromosome maintenance complex component 10
MECOM MDS1 and EVI1 complex locus
MEF2D myocyte enhancer factor 2D
MEN1 multiple endocrine neoplasia I
MIR126 microRNA 126
MIR132 microRNA 132
MIR142 microRNA 142
MIR181C microRNA 181c
MIR200A microRNA 200a
MIR204 microRNA 204
MIR21 microRNA 21
MIR217 microRNA 217
MIR221 microRNA 221
MIR222 microRNA 222
MIR29C microRNA 29c
MIR34A microRNA 34a
MIR486-1 microRNA 486-1
MIR486-2 microRNA 486-2
MIRLET7I microRNA let-7i
MLH1 mutL homolog 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MST1 macrophage stimulating 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NBN nibrin
NCF1 neutrophil cytosolic factor 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2E1 nuclear receptor subfamily 2, group E, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PARP1 poly (ADP-ribose) polymerase 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PGAM1 phosphoglycerate mutase 1 (brain)
PIAS4 protein inhibitor of activated STAT, 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
POU5F1 POU class 5 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSEN1 presenilin 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTAFR platelet-activating factor receptor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS19BP1 ribosomal protein S19 binding protein 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SETD7 SET domain containing (lysine methyltransferase) 7
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SIRT3 sirtuin 3
SIRT6 sirtuin 6
SKI SKI proto-oncogene
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SNW1 SNW domain containing 1
SOD2 superoxide dismutase 2, mitochondrial
SOST sclerostin
SP1 Sp1 transcription factor
SREBF1 sterol regulatory element binding transcription factor 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
STRADA STE20-related kinase adaptor alpha
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAL1 T-cell acute lymphocytic leukemia 1
TDG thymine-DNA glycosylase
TERT telomerase reverse transcriptase
TH tyrosine hydroxylase
THRB thyroid hormone receptor, beta
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
VASH1 vasohibin 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WRN Werner syndrome, RecQ helicase-like
XBP1 X-box binding protein 1
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZG16B zymogen granule protein 16B