sirt2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description sirtuin 2|This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 22933)
Similar Terms
Downloads & Tools

Genes

30 genes co-occuring with the biological term sirt2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOE apolipoprotein E
ATG7 autophagy related 7
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CDKN2A cyclin-dependent kinase inhibitor 2A
CSK c-src tyrosine kinase
EIF5A eukaryotic translation initiation factor 5A
ELP3 elongator acetyltransferase complex subunit 3
EP300 E1A binding protein p300
FOXO3 forkhead box O3
FRY furry homolog (Drosophila)
G6PD glucose-6-phosphate dehydrogenase
HDAC6 histone deacetylase 6
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOXA10 homeobox A10
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
JAK3 Janus kinase 3
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT8 keratin 8, type II
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR21 microRNA 21
PSEN1 presenilin 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SIRT1 sirtuin 1
SIRT2 sirtuin 2
TP53 tumor protein p53
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta