sitosterol-2912 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the sitosterol-2912 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADORA1 adenosine A1 receptor
ANGPTL2 angiopoietin-like 2
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATXN2L ataxin 2-like
C11ORF16 chromosome 11 open reading frame 16
C16ORF45 chromosome 16 open reading frame 45
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CARD10 caspase recruitment domain family, member 10
CCDC64 coiled-coil domain containing 64
CD59 CD59 molecule, complement regulatory protein
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CECR1 cat eye syndrome chromosome region, candidate 1
CLCN4 chloride channel, voltage-sensitive 4
CLCN7 chloride channel, voltage-sensitive 7
CLEC4A C-type lectin domain family 4, member A
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTSZ cathepsin Z
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
EFNA3 ephrin-A3
EPN2 epsin 2
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FPR2 formyl peptide receptor 2
FRMPD1 FERM and PDZ domain containing 1
GAL galanin/GMAP prepropeptide
HIST1H2BO histone cluster 1, H2bo
HMG20B high mobility group 20B
HRAS Harvey rat sarcoma viral oncogene homolog
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
IGHMBP2 immunoglobulin mu binding protein 2
KIAA0040 KIAA0040
KIFC3 kinesin family member C3
LOX lysyl oxidase
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRP5 low density lipoprotein receptor-related protein 5
LRRC41 leucine rich repeat containing 41
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MARC1 mitochondrial amidoxime reducing component 1
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MFGE8 milk fat globule-EGF factor 8 protein
MLXIP MLX interacting protein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MRPS12 mitochondrial ribosomal protein S12
NUP188 nucleoporin 188kDa
NYX nyctalopin
PCDH17 protocadherin 17
PHF7 PHD finger protein 7
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLSCR3 phospholipid scramblase 3
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRDX2 peroxiredoxin 2
PRKCQ protein kinase C, theta
PTEN phosphatase and tensin homolog
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBFA ribosome binding factor A (putative)
RGS10 regulator of G-protein signaling 10
RNF17 ring finger protein 17
RPL7 ribosomal protein L7
RTEL1 regulator of telomere elongation helicase 1
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SLAMF8 SLAM family member 8
SP140 SP140 nuclear body protein
SPATA20 spermatogenesis associated 20
SPHK2 sphingosine kinase 2
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAPT1 transmembrane anterior posterior transformation 1
TBXA2R thromboxane A2 receptor
TCP11L1 t-complex 11, testis-specific-like 1
THAP3 THAP domain containing, apoptosis associated protein 3
TLDC1 TBC/LysM-associated domain containing 1
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRBC1 T cell receptor beta constant 1
TRIM48 tripartite motif containing 48
TSNAXIP1 translin-associated factor X interacting protein 1
TSPAN4 tetraspanin 4
TYMP thymidine phosphorylase
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZER1 zyg-11 related, cell cycle regulator
ZNF609 zinc finger protein 609
ZNF614 zinc finger protein 614
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACPP acid phosphatase, prostate
AGBL5 ATP/GTP binding protein-like 5
AIM2 absent in melanoma 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL15 ADP-ribosylation factor-like 15
ASB13 ankyrin repeat and SOCS box containing 13
BAHD1 bromo adjacent homology domain containing 1
C17ORF80 chromosome 17 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
C5 complement component 5
CARF calcium responsive transcription factor
CD37 CD37 molecule
CGREF1 cell growth regulator with EF-hand domain 1
CHST10 carbohydrate sulfotransferase 10
CIC capicua transcriptional repressor
CRIP1 cysteine-rich protein 1 (intestinal)
CXORF56 chromosome X open reading frame 56
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPY19L2P2 DPY19L2 pseudogene 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM188A family with sequence similarity 188, member A
FBXL6 F-box and leucine-rich repeat protein 6
FGL2 fibrinogen-like 2
FKBP5 FK506 binding protein 5
FKBPL FK506 binding protein like
FLJ10038 uncharacterized protein FLJ10038
FOSL1 FOS-like antigen 1
GBAS glioblastoma amplified sequence
GDAP1 ganglioside induced differentiation associated protein 1
GID4 GID complex subunit 4
GMPPB GDP-mannose pyrophosphorylase B
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR27 G protein-coupled receptor 27
GPR65 G protein-coupled receptor 65
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF2I general transcription factor IIi
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AG histone cluster 1, H2ag
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFLR1 IGF-like family receptor 1
IMPAD1 inositol monophosphatase domain containing 1
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INCENP inner centromere protein antigens 135/155kDa
ITGB7 integrin, beta 7
ITPKB inositol-trisphosphate 3-kinase B
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCTD20 potassium channel tetramerization domain containing 20
KIAA0196 KIAA0196
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRI1 KRI1 homolog (S. cerevisiae)
LINC00597 long intergenic non-protein coding RNA 597
LOC157562 uncharacterized LOC157562
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MIR22HG MIR22 host gene
MLH3 mutL homolog 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL44 mitochondrial ribosomal protein L44
MTERF4 mitochondrial transcription termination factor 4
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
NAT6 N-acetyltransferase 6 (GCN5-related)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OLAH oleoyl-ACP hydrolase
PADI2 peptidyl arginine deiminase, type II
PARP16 poly (ADP-ribose) polymerase family, member 16
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PSKH1 protein serine kinase H1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RRAGB Ras-related GTP binding B
SALL2 spalt-like transcription factor 2
SERGEF secretion regulating guanine nucleotide exchange factor
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIRAL2 SIR2 antiphage like 2
SKI SKI proto-oncogene
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A6 solute carrier family 38, member 6
SOCS6 suppressor of cytokine signaling 6
STX1A syntaxin 1A (brain)
TASP1 taspase, threonine aspartase, 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THAP10 THAP domain containing 10
TMEM242 transmembrane protein 242
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC22D4 TSC22 domain family, member 4
VCPKMT valosin containing protein lysine (K) methyltransferase
ZBTB39 zinc finger and BTB domain containing 39
ZC3H3 zinc finger CCCH-type containing 3
ZC4H2 zinc finger, C4H2 domain containing
ZEB2 zinc finger E-box binding homeobox 2
ZNF701 zinc finger protein 701
ZNF770 zinc finger protein 770
ZNF816 zinc finger protein 816
ZNHIT2 zinc finger, HIT-type containing 2