sitosterol-7332 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the sitosterol-7332 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGMAT agmatine ureohydrolase (agmatinase)
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALK anaplastic lymphoma receptor tyrosine kinase
ALS2CL ALS2 C-terminal like
APOE apolipoprotein E
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD8A CD8a molecule
CDHR2 cadherin-related family member 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLCN6 chloride channel, voltage-sensitive 6
COL6A1 collagen, type VI, alpha 1
CPA2 carboxypeptidase A2 (pancreatic)
CST6 cystatin E/M
DHRS12 dehydrogenase/reductase (SDR family) member 12
DOCK5 dedicator of cytokinesis 5
EEA1 early endosome antigen 1
EHBP1L1 EH domain binding protein 1-like 1
ELP6 elongator acetyltransferase complex subunit 6
FANCA Fanconi anemia, complementation group A
FGFR1 fibroblast growth factor receptor 1
FGL1 fibrinogen-like 1
FH fumarate hydratase
FSCN1 fascin actin-bundling protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GM2A GM2 ganglioside activator
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR19 G protein-coupled receptor 19
GRM8 glutamate receptor, metabotropic 8
GSTA3 glutathione S-transferase alpha 3
HIST1H2BN histone cluster 1, H2bn
HIST1H4E histone cluster 1, H4e
HNF4A hepatocyte nuclear factor 4, alpha
HR hair growth associated
IFNAR1 interferon (alpha, beta and omega) receptor 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
LMF2 lipase maturation factor 2
LTBP4 latent transforming growth factor beta binding protein 4
MAP1A microtubule-associated protein 1A
MOCS1 molybdenum cofactor synthesis 1
MTA1 metastasis associated 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NEUROD4 neuronal differentiation 4
NF1 neurofibromin 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
ORAI2 ORAI calcium release-activated calcium modulator 2
OVOL2 ovo-like zinc finger 2
PCGF3 polycomb group ring finger 3
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PER3 period circadian clock 3
PHEX phosphate regulating endopeptidase homolog, X-linked
PLAC1 placenta-specific 1
PLIN2 perilipin 2
PMEL premelanosome protein
PPAP2B phosphatidic acid phosphatase type 2B
PRDX2 peroxiredoxin 2
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PXN paxillin
RABGAP1L RAB GTPase activating protein 1-like
RALGDS ral guanine nucleotide dissociation stimulator
RRAGD Ras-related GTP binding D
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RSU1 Ras suppressor protein 1
S100A9 S100 calcium binding protein A9
SERGEF secretion regulating guanine nucleotide exchange factor
SH3GL3 SH3-domain GRB2-like 3
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SSPN sarcospan
STON1 stonin 1
TBC1D22A TBC1 domain family, member 22A
TCTN2 tectonic family member 2
THBD thrombomodulin
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TJAP1 tight junction associated protein 1 (peripheral)
TMEM212 transmembrane protein 212
TMEM254 transmembrane protein 254
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WAS Wiskott-Aldrich syndrome
WDR19 WD repeat domain 19
WDTC1 WD and tetratricopeptide repeats 1
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZFHX4 zinc finger homeobox 4
ZFX zinc finger protein, X-linked
ZNF589 zinc finger protein 589
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADAP2 ArfGAP with dual PH domains 2
ANXA2P3 annexin A2 pseudogene 3
APOC1 apolipoprotein C-I
ASAP1-IT1 ASAP1 intronic transcript 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD3A ATPase family, AAA domain containing 3A
AXIN1 axin 1
BMP4 bone morphogenetic protein 4
BPGM 2,3-bisphosphoglycerate mutase
C11ORF30 chromosome 11 open reading frame 30
C9ORF91 chromosome 9 open reading frame 91
CA11 carbonic anhydrase XI
CBX7 chromobox homolog 7
CBX8 chromobox homolog 8
CEP170B centrosomal protein 170B
CEP85 centrosomal protein 85kDa
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLDN15 claudin 15
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DMC1 DNA meiotic recombinase 1
EPHA2 EPH receptor A2
ERO1L ERO1-like (S. cerevisiae)
F8 coagulation factor VIII, procoagulant component
FANCE Fanconi anemia, complementation group E
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GAN gigaxonin
GPATCH2L G patch domain containing 2-like
GPC3 glypican 3
GPRASP1 G protein-coupled receptor associated sorting protein 1
GSTCD glutathione S-transferase, C-terminal domain containing
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIST1H1D histone cluster 1, H1d
HIST1H3B histone cluster 1, H3b
HIST2H2AA3 histone cluster 2, H2aa3
HOXC10 homeobox C10
HSPA2 heat shock 70kDa protein 2
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IL17RA interleukin 17 receptor A
IRAK4 interleukin-1 receptor-associated kinase 4
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIF13B kinesin family member 13B
LAMB3 laminin, beta 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHFPL2 lipoma HMGIC fusion partner-like 2
LIG4 ligase IV, DNA, ATP-dependent
LOC730101 uncharacterized LOC730101
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LYPD1 LY6/PLAUR domain containing 1
MAP9 microtubule-associated protein 9
MXD3 MAX dimerization protein 3
NBEAL2 neurobeachin-like 2
NEK11 NIMA-related kinase 11
NPFFR1 neuropeptide FF receptor 1
PARG poly (ADP-ribose) glycohydrolase
PGP phosphoglycolate phosphatase
PILRB paired immunoglobin-like type 2 receptor beta
PLD2 phospholipase D2
PODXL2 podocalyxin-like 2
PTPRU protein tyrosine phosphatase, receptor type, U
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SH2D4A SH2 domain containing 4A
SLC46A3 solute carrier family 46, member 3
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D17 TBC1 domain family, member 17
TESK1 testis-specific kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TMC7 transmembrane channel-like 7
TMEM120B transmembrane protein 120B
TMEM121 transmembrane protein 121
TMEM2 transmembrane protein 2
TMEM57 transmembrane protein 57
TNRC6B trinucleotide repeat containing 6B
TNS2 tensin 2
TPCN1 two pore segment channel 1
TPST2 tyrosylprotein sulfotransferase 2
TRAIP TRAF interacting protein
TUBGCP5 tubulin, gamma complex associated protein 5
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VAV1 vav 1 guanine nucleotide exchange factor
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XYLT2 xylosyltransferase II
ZNF141 zinc finger protein 141
ZNF280D zinc finger protein 280D
ZNF701 zinc finger protein 701
ZNF862 zinc finger protein 862
ZSCAN31 zinc finger and SCAN domain containing 31