skeletal system development Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). (Gene Ontology, GO_0001501)
External Link http://amigo.geneontology.org/amigo/term/GO:0001501
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Genes

161 genes participating in the skeletal system development biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACAN aggrecan
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
AHSG alpha-2-HS-glycoprotein
AKAP13 A kinase (PRKA) anchor protein 13
ALPL alkaline phosphatase, liver/bone/kidney
ALX4 ALX homeobox 4
ANKH ANKH inorganic pyrophosphate transport regulator
ANKRD11 ankyrin repeat domain 11
ARSL arylsulfatase L
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BCAN brevican
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP1 bone morphogenetic protein 1
BMP2 bone morphogenetic protein 2
BMP3 bone morphogenetic protein 3
BMP5 bone morphogenetic protein 5
BMP6 bone morphogenetic protein 6
BMP7 bone morphogenetic protein 7
BMP8B bone morphogenetic protein 8b
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2
CD44 CD44 molecule (Indian blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHD7 chromodomain helicase DNA binding protein 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRD chordin
CLEC3A C-type lectin domain family 3, member A
CMKLR1 chemerin chemokine-like receptor 1
CNMD chondromodulin
COL10A1 collagen, type X, alpha 1
COL11A2 collagen, type XI, alpha 2
COL13A1 collagen, type XIII, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL19A1 collagen, type XIX, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL27A1 collagen, type XXVII, alpha 1
COL2A1 collagen, type II, alpha 1
COL9A2 collagen, type IX, alpha 2
COMP cartilage oligomeric matrix protein
CREB3L2 cAMP responsive element binding protein 3-like 2
DDRGK1 DDRGK domain containing 1
DEAF1 DEAF1 transcription factor
DLL3 delta-like 3 (Drosophila)
DLX1 distal-less homeobox 1
DLX2 distal-less homeobox 2
DLX3 distal-less homeobox 3
DLX4 distal-less homeobox 4
DLX5 distal-less homeobox 5
DLX6 distal-less homeobox 6
DYM dymeclin
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EN1 engrailed homeobox 1
EPYC epiphycan
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EVC Ellis van Creveld protein
EXTL1 exostosin-like glycosyltransferase 1
FBN1 fibrillin 1
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FRZB frizzled-related protein
GDF10 growth differentiation factor 10
GDF11 growth differentiation factor 11
GDF2 growth differentiation factor 2
GDF3 growth differentiation factor 3
GHRL ghrelin/obestatin prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GLI2 GLI family zinc finger 2
GNAS GNAS complex locus
HAPLN1 hyaluronan and proteoglycan link protein 1
HAPLN2 hyaluronan and proteoglycan link protein 2
HAPLN3 hyaluronan and proteoglycan link protein 3
HAPLN4 hyaluronan and proteoglycan link protein 4
HES5 hes family bHLH transcription factor 5
HHIP hedgehog interacting protein
HOXA11 homeobox A11
HOXA13 homeobox A13
HOXD3 homeobox D3
HYAL2 hyaluronoglucosaminidase 2
HYAL3 hyaluronoglucosaminidase 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IHH indian hedgehog
IL17F interleukin 17F
INHA inhibin, alpha
ITGB8 integrin, beta 8
KIAA1217 KIAA1217
LAMA5 laminin, alpha 5
LECT2 leukocyte cell-derived chemotaxin 2
MATN3 matrilin 3
MEPE matrix extracellular phosphoglycoprotein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MRPL13 mitochondrial ribosomal protein L13
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCAN neurocan
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NKX3-2 NK3 homeobox 2
NOG noggin
NOTUM notum pectinacetylesterase homolog (Drosophila)
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
OGN osteoglycin
OPTC opticin
P3H1 prolyl 3-hydroxylase 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PAX1 paired box 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PHEX phosphate regulating endopeptidase homolog, X-linked
PITX1 paired-like homeodomain 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKDCC protein kinase domain containing, cytoplasmic
PLS3 plastin 3
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRDX1 peroxiredoxin 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTH1R parathyroid hormone 1 receptor
PTHLH parathyroid hormone-like hormone
PTRH2 peptidyl-tRNA hydrolase 2
RAB33B RAB33B, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
RFLNA refilin A
RFLNB refilin B
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SGPP2 sphingosine-1-phosphate phosphatase 2
SH3PXD2B SH3 and PX domains 2B
SHOX short stature homeobox
SHOX2 short stature homeobox 2
SLC10A7 solute carrier family 10, member 7
SNORC secondary ossification center associated regulator of chondrocyte maturation
SOX5 SRY (sex determining region Y)-box 5
SOX6 SRY (sex determining region Y)-box 6
SOX9 SRY (sex determining region Y)-box 9
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPEF2 sperm flagellar 2
STC1 stanniocalcin 1
SULF1 sulfatase 1
SULF2 sulfatase 2
TBX3 T-box 3
TBX4 T-box 4
TCOF1 Treacher Collins-Franceschetti syndrome 1
TEAD4 TEA domain family member 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
TGM2 transglutaminase 2
TLL1 tolloid-like 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRAPPC2 trafficking protein particle complex 2
TRIP11 thyroid hormone receptor interactor 11
TRPS1 trichorhinophalangeal syndrome I
UCMA upper zone of growth plate and cartilage matrix associated
UFD1 ubiquitin recognition factor in ER associated degradation 1
VCAN versican
VKORC1 vitamin K epoxide reductase complex, subunit 1
WNT1 wingless-type MMTV integration site family, member 1
WNT11 wingless-type MMTV integration site family, member 11
WNT5A wingless-type MMTV integration site family, member 5A
WWOX WW domain containing oxidoreductase
XYLT1 xylosyltransferase I
ZBTB16 zinc finger and BTB domain containing 16