skp2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description S-phase kinase-associated protein 2, E3 ubiquitin protein ligase|This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 6502)
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Genes

79 genes co-occuring with the biological term skp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANAPC1 anaphase promoting complex subunit 1
AR androgen receptor
ATM ATM serine/threonine kinase
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BRCA2 breast cancer 2, early onset
CAND1 cullin-associated and neddylation-dissociated 1
CCND3 cyclin D3
CCNE1 cyclin E1
CDK2 cyclin-dependent kinase 2
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CHUK conserved helix-loop-helix ubiquitous kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS1BP7 CDC28 protein kinase regulatory subunit 1B pseudogene 7
COPS5 COP9 signalosome subunit 5
CTTN cortactin
CUL1 cullin 1
CUL3 cullin 3
CUL4A cullin 4A
DDB1 damage-specific DNA binding protein 1, 127kDa
DUSP1 dual specificity phosphatase 1
E2F1 E2F transcription factor 1
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
FBXO31 F-box protein 31
FBXO5 F-box protein 5
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GSK3B glycogen synthase kinase 3 beta
HDAC3 histone deacetylase 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL16 interleukin 16
IL2 interleukin 2
ING4 inhibitor of growth family, member 4
KAT8 K(lysine) acetyltransferase 8
KIF14 kinesin family member 14
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NOTCH1 notch 1
NOTCH3 notch 3
PHB2 prohibitin 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PPARG peroxisome proliferator-activated receptor gamma
PRKCI protein kinase C, iota
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
RAG2 recombination activating gene 2
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOA ras homolog family member A
RND3 Rho family GTPase 3
SAMHD1 SAM domain and HD domain 1
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD7 SMAD family member 7
SP1 Sp1 transcription factor
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TP53 tumor protein p53
TSC2 tuberous sclerosis 2
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WIF1 WNT inhibitory factor 1