sle Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. (Experimental Factor Ontology, EFO_0002690)
Similar Terms
Downloads & Tools

Genes

305 genes co-occuring with the biological term sle in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACP1 acid phosphatase 1, soluble
ADAR adenosine deaminase, RNA-specific
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AIM2 absent in melanoma 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA1 annexin A1
ANXA5 annexin A5
APOH apolipoprotein H (beta-2-glycoprotein I)
APOL1 apolipoprotein L, 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATG5 autophagy related 5
B2M beta-2-microglobulin
BANK1 B-cell scaffold protein with ankyrin repeats 1
BLK BLK proto-oncogene, Src family tyrosine kinase
BTLA B and T lymphocyte associated
C1QC complement component 1, q subcomponent, C chain
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
CALCA calcitonin-related polypeptide alpha
CAMP cathelicidin antimicrobial peptide
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAT catalase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL14 chemokine (C-C motif) ligand 14
CCL17 chemokine (C-C motif) ligand 17
CCL2 chemokine (C-C motif) ligand 2
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL5 chemokine (C-C motif) ligand 5
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD19 CD19 molecule
CD1D CD1d molecule
CD22 CD22 molecule
CD226 CD226 molecule
CD24 CD24 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD247 CD247 molecule
CD27 CD27 molecule
CD274 CD274 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD70 CD70 molecule
CD72 CD72 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CFH complement factor H
CIITA class II, major histocompatibility complex, transactivator
CISH cytokine inducible SH2-containing protein
CLEC4C C-type lectin domain family 4, member C
CNBP CCHC-type zinc finger, nucleic acid binding protein
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CREM cAMP responsive element modulator
CRLS1 cardiolipin synthase 1
CRP C-reactive protein, pentraxin-related
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DEFA3 defensin, alpha 3, neutrophil-specific
DNASE1 deoxyribonuclease I
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EGR2 early growth response 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELK1 ELK1, member of ETS oncogene family
ERN1 endoplasmic reticulum to nucleus signaling 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F2 coagulation factor II (thrombin)
FADD Fas (TNFRSF6)-associated via death domain
FAM167A family with sequence similarity 167, member A
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
FOXP3 forkhead box P3
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GAS6 growth arrest-specific 6
GHRL ghrelin/obestatin prepropeptide
GSTM1 glutathione S-transferase mu 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST2H2BE histone cluster 2, H2be
HLA-C major histocompatibility complex, class I, C
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IFIH1 interferon induced with helicase C domain 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNA1 interferon, alpha 1
IFNA2 interferon, alpha 2
IFNA5 interferon, alpha 5
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL17A interleukin 17A
IL17F interleukin 17F
IL18 interleukin 18
IL18BP interleukin 18 binding protein
IL1A interleukin 1, alpha
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL37 interleukin 37
IL4 interleukin 4
IL6 interleukin 6
INS insulin
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
IRF8 interferon regulatory factor 8
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KDR kinase insert domain receptor
KIAA0319L KIAA0319-like
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KLRD1 killer cell lectin-like receptor subfamily D, member 1
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LCE3B late cornified envelope 3B
LCE3C late cornified envelope 3C
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LIG4 ligase IV, DNA, ATP-dependent
LMAN1 lectin, mannose-binding, 1
LPA lipoprotein, Lp(a)
LTA lymphotoxin alpha
MAPK1 mitogen-activated protein kinase 1
MBD2 methyl-CpG binding domain protein 2
MBD4 methyl-CpG binding domain protein 4
MBL2 mannose-binding lectin (protein C) 2, soluble
MEFV Mediterranean fever
MERTK MER proto-oncogene, tyrosine kinase
MFGE8 milk fat globule-EGF factor 8 protein
MICA MHC class I polypeptide-related sequence A
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR146A microRNA 146a
MIR155 microRNA 155
MIR21 microRNA 21
MIR516A1 microRNA 516a-1
MIR516A2 microRNA 516a-2
MIR525 microRNA 525
MIR629 microRNA 629
MMP9 matrix metallopeptidase 9
MSN moesin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC16 mucin 16, cell surface associated
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCF2 neutrophil cytosolic factor 2
NCR2 natural cytotoxicity triggering receptor 2
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NRP1 neuropilin 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PCNA proliferating cell nuclear antigen
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLAUR plasminogen activator, urokinase receptor
PLCB2 phospholipase C, beta 2
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRDM1 PR domain containing 1, with ZNF domain
PRF1 perforin 1 (pore forming protein)
PRL prolactin
PRLR prolactin receptor
PROS1 protein S (alpha)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RABGAP1L RAB GTPase activating protein 1-like
RAD52 RAD52 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RDX radixin
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPLP0 ribosomal protein, large, P0
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SELE selectin E
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT2 septin 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLAMF6 SLAM family member 6
SLAMF7 SLAM family member 7
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLEB3 systemic lupus erythematosus susceptibility 3
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SPN sialophorin
SPP1 secreted phosphoprotein 1
SRSF1 serine/arginine-rich splicing factor 1
SSB Sjogren syndrome antigen B (autoantigen La)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK17A serine/threonine kinase 17a
SYK spleen tyrosine kinase
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBK1 TANK-binding kinase 1
TBX21 T-box 21
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF3IP2 TRAF3 interacting protein 2
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TYK2 tyrosine kinase 2
UHRF1BP1 UHRF1 binding protein 1
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZNF423 zinc finger protein 423