sleep Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. (Gene Ontology, GO_0030431)
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Genes

180 genes co-occuring with the biological term sleep in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACE angiotensin I converting enzyme
ADA adenosine deaminase
ADAM29 ADAM metallopeptidase domain 29
ADIPOQ adiponectin, C1Q and collagen domain containing
ADK adenosine kinase
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADRB1 adrenoceptor beta 1
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHDC1 AT hook, DNA binding motif, containing 1
AHSG alpha-2-HS-glycoprotein
ALB albumin
ANKK1 ankyrin repeat and kinase domain containing 1
APLN apelin
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMT acetylserotonin O-methyltransferase
ATN1 atrophin 1
BAX BCL2-associated X protein
BDNF brain-derived neurotrophic factor
BHLHE41 basic helix-loop-helix family, member e41
BTBD9 BTB (POZ) domain containing 9
CALCA calcitonin-related polypeptide alpha
CCL2 chemokine (C-C motif) ligand 2
CD40LG CD40 ligand
CDKL5 cyclin-dependent kinase-like 5
CHD8 chromodomain helicase DNA binding protein 8
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIT1 chitinase 1 (chitotriosidase)
CLOCK clock circadian regulator
COMT catechol-O-methyltransferase
COPA coatomer protein complex, subunit alpha
CRP C-reactive protein, pentraxin-related
CRY2 cryptochrome circadian clock 2
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
ELP3 elongator acetyltransferase complex subunit 3
ENO2 enolase 2 (gamma, neuronal)
EPO erythropoietin
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FABP4 fatty acid binding protein 4, adipocyte
FFAR4 free fatty acid receptor 4
FLRT2 fibronectin leucine rich transmembrane protein 2
FMR1 fragile X mental retardation 1
FOXP3 forkhead box P3
FTH1 ferritin, heavy polypeptide 1
FTO fat mass and obesity associated
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GCG glucagon
GH1 growth hormone 1
GHRH growth hormone releasing hormone
GHRL ghrelin/obestatin prepropeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRIA3 glutamate receptor, ionotropic, AMPA 3
GSK3B glycogen synthase kinase 3 beta
HBA1 hemoglobin, alpha 1
HCRT hypocretin (orexin) neuropeptide precursor
HCRTR1 hypocretin (orexin) receptor 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HRH3 histamine receptor H3
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
IL6R interleukin 6 receptor
IL7 interleukin 7
IRS1 insulin receptor substrate 1
ITLN1 intelectin 1 (galactofuranose binding)
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
LBP lipopolysaccharide binding protein
LEP leptin
LEPR leptin receptor
LMNA lamin A/C
LPL lipoprotein lipase
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCL1 myeloid cell leukemia 1
MECP2 methyl CpG binding protein 2
MEIS1 Meis homeobox 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1B melatonin receptor 1B
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRXN3 neurexin 3
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPN4 opsin 4
OXT oxytocin/neurophysin I prepropeptide
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARK2 parkin RBR E3 ubiquitin protein ligase
PDGFB platelet-derived growth factor beta polypeptide
PER1 period circadian clock 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PHOX2B paired-like homeobox 2b
PINK1 PTEN induced putative kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROK2 prokineticin 2
PROKR2 prokineticin receptor 2
PSEN1 presenilin 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTPRD protein tyrosine phosphatase, receptor type, D
RBP4 retinol binding protein 4, plasma
REN renin
RETN resistin
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SAA1 serum amyloid A1
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOD1 superoxide dismutase 1, soluble
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TEF thyrotrophic embryonic factor
TGFB1 transforming growth factor, beta 1
TMEM18 transmembrane protein 18
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOX3 TOX high mobility group box family member 3
TRIB1 tribbles pseudokinase 1
UBE3A ubiquitin protein ligase E3A
VEGFA vascular endothelial growth factor A