sleeping sickness Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances. (Human Disease Ontology, DOID_10112)
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Genes

178 genes co-occuring with the disease sleeping sickness in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
APOL1 apolipoprotein L, 1 2.26586
TBPL1 TBP-like 1 1.94924
ODC1 ornithine decarboxylase 1 1.67593
SRM spermidine synthase 1.55601
CPZ carboxypeptidase Z 1.38734
AMD1 adenosylmethionine decarboxylase 1 1.35725
DNAH10 dynein, axonemal, heavy chain 10 1.3555
TWF1 twinfilin actin binding protein 1 1.31231
HPR haptoglobin-related protein 1.26473
CTSL cathepsin L 1.23516
CD200R1L CD200 receptor 1-like 1.15709
TBCCD1 TBCC domain containing 1 1.14772
PAPD4 PAP associated domain containing 4 1.11099
TBR1 T-box, brain, 1 1.10973
ADK adenosine kinase 1.09881
GSR glutathione reductase 1.06606
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 1.0627
RBKS ribokinase 1.03956
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 1.01891
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 0.99233
MARS methionyl-tRNA synthetase 0.99233
GALE UDP-galactose-4-epimerase 0.962053
DHFR dihydrofolate reductase 0.94577
FARSB phenylalanyl-tRNA synthetase, beta subunit 0.940364
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 0.938704
CHN2 chimerin 2 0.929587
POLI polymerase (DNA directed) iota 0.897872
COX6CP4 cytochrome c oxidase subunit VIc pseudogene 4 0.876557
ACSS2 acyl-CoA synthetase short-chain family member 2 0.862228
NTSR1 neurotensin receptor 1 (high affinity) 0.854449
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.821257
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.814693
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.808949
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.806077
ADSL adenylosuccinate lyase 0.798282
TNF tumor necrosis factor 0.795411
CTSB cathepsin B 0.794181
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.786803
LAP3 leucine aminopeptidase 3 0.772479
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.767576
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 0.761862
CXCL13 chemokine (C-X-C motif) ligand 13 0.74436
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 0.733406
MAT2A methionine adenosyltransferase II, alpha 0.721673
COG8 component of oligomeric golgi complex 8 0.715215
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.701928
TF transferrin 0.700321
VARS valyl-tRNA synthetase 0.695103
DOHH deoxyhypusine hydroxylase/monooxygenase 0.690293
PGM2 phosphoglucomutase 2 0.680697
TMSB10 thymosin beta 10 0.680297
CTPS1 CTP synthase 1 0.66755
SPAG6 sperm associated antigen 6 0.635528
CXCL10 chemokine (C-X-C motif) ligand 10 0.628065
HP haptoglobin 0.617486
MAT1A methionine adenosyltransferase I, alpha 0.612401
CDC6 cell division cycle 6 0.593674
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 0.588222
DOCK4 dedicator of cytokinesis 4 0.580439
GTSE1 G-2 and S-phase expressed 1 0.574605
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.573439
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 0.573439
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 0.572273
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.571107
CC2D2A coiled-coil and C2 domain containing 2A 0.557509
NMT1 N-myristoyltransferase 1 0.554403
GALC galactosylceramidase 0.551298
SEC63 SEC63 homolog (S. cerevisiae) 0.532314
SARS seryl-tRNA synthetase 0.531928
APOA1 apolipoprotein A-I 0.529994
LARS leucyl-tRNA synthetase 0.521888
FDPS farnesyl diphosphate synthase 0.503441
IL10 interleukin 10 0.495029
MKS1 Meckel syndrome, type 1 0.493122
FBXO17 F-box protein 17 0.485505
TFRC transferrin receptor 0.474498
ANTXR2 anthrax toxin receptor 2 0.474119
PEX14 peroxisomal biogenesis factor 14 0.471468
TIMELESS timeless circadian clock 0.471468
NARS asparaginyl-tRNA synthetase 0.468819
PTMS parathymosin 0.463905
PDE4A phosphodiesterase 4A, cAMP-specific 0.461639
OAZ1 ornithine decarboxylase antizyme 1 0.461261
RAE1 ribonucleic acid export 1 0.460506
SMS spermine synthase 0.457109
PAPD7 PAP associated domain containing 7 0.455601
SQLE squalene epoxidase 0.444676
UGP2 UDP-glucose pyrophosphorylase 2 0.443923
NOS2 nitric oxide synthase 2, inducible 0.434899
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.433397
DNAI1 dynein, axonemal, intermediate chain 1 0.43227
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.42364
USP18 ubiquitin specific peptidase 18 0.422515
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.413901
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.411283
AANAT aralkylamine N-acetyltransferase 0.409787
DNAH9 dynein, axonemal, heavy chain 9 0.408292
CD244 CD244 molecule, natural killer cell receptor 2B4 0.407919
UTS2R urotensin 2 receptor 0.407545
ARL6 ADP-ribosylation factor-like 6 0.404931
AFM afamin 0.404557
CPB2 carboxypeptidase B2 (plasma) 0.403438
CD1D CD1d molecule 0.398962
PKD2L1 polycystic kidney disease 2-like 1 0.39598
VCAM1 vascular cell adhesion molecule 1 0.39598
ICAM1 intercellular adhesion molecule 1 0.386679
SLC46A1 solute carrier family 46 (folate transporter), member 1 0.385936
OFD1 oral-facial-digital syndrome 1 0.384451
TST thiosulfate sulfurtransferase (rhodanese) 0.378885
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.377402
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.37592
SET SET nuclear proto-oncogene 0.373698
ADA adenosine deaminase 0.369258
GTF2B general transcription factor IIB 0.366301
GLRX glutaredoxin (thioltransferase) 0.364454
MYH9 myosin, heavy chain 9, non-muscle 0.364085
CD200R1 CD200 receptor 1 0.357077
RETNLB resistin like beta 0.356341
SATB2 SATB homeobox 2 0.35082
ABAT 4-aminobutyrate aminotransferase 0.348981
PFKM phosphofructokinase, muscle 0.347144
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.345308
SRRM1 serine/arginine repetitive matrix 1 0.34384
AARS alanyl-tRNA synthetase 0.337608
TACR1 tachykinin receptor 1 0.337242
UPP1 uridine phosphorylase 1 0.333949
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.323365
SLC22A18 solute carrier family 22, member 18 0.319726
CTRL chymotrypsin-like 0.315729
PPP5C protein phosphatase 5, catalytic subunit 0.311739
ALB albumin 0.311014
HVCN1 hydrogen voltage gated channel 1 0.308842
CPA6 carboxypeptidase A6 0.30848
CCL3 chemokine (C-C motif) ligand 3 0.305587
ACTA2 actin, alpha 2, smooth muscle, aorta 0.294053
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.294053
STK38 serine/threonine kinase 38 0.284013
CD4 CD4 molecule 0.27687
MT3 metallothionein 3 0.275801
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 0.27153
IL1A interleukin 1, alpha 0.269398
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 0.266558
IL2 interleukin 2 0.251718
DHPS deoxyhypusine synthase 0.251015
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 0.24996
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.242245
TAC1 tachykinin, precursor 1 0.239799
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.233183
DHODH dihydroorotate dehydrogenase (quinone) 0.232142
IPP intracisternal A particle-promoted polypeptide 0.229716
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.229024
GFER growth factor, augmenter of liver regeneration 0.221793
TARS threonyl-tRNA synthetase 0.220424
SIRT5 sirtuin 5 0.219057
SIRT4 sirtuin 4 0.218374
IGHV1-2 immunoglobulin heavy variable 1-2 0.217693
DNM2 dynamin 2 0.213621
SIRT7 sirtuin 7 0.210253
G6PD glucose-6-phosphate dehydrogenase 0.209918
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.205254
DAXX death-domain associated protein 0.202618
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.200331
NSF N-ethylmaleimide-sensitive factor 0.198709
CD200 CD200 molecule 0.195501
AHCY adenosylhomocysteinase 0.194865
IFNG interferon, gamma 0.193915
HK1 hexokinase 1 0.182375
HES5 hes family bHLH transcription factor 5 0.181798
PREP prolyl endopeptidase 0.180084
PDE5A phosphodiesterase 5A, cGMP-specific 0.174881
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.173832
IL2RA interleukin 2 receptor, alpha 0.171036
SIRT6 sirtuin 6 0.170789
MTAP methylthioadenosine phosphorylase 0.170054
WARS tryptophanyl-tRNA synthetase 0.167915
CTSS cathepsin S 0.161331
IFNGR1 interferon gamma receptor 1 0.160948
TK1 thymidine kinase 1, soluble 0.158605