slit diaphragm Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. (Gene Ontology, GO_0036057)
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Genes

98 proteins co-occuring with the slit diaphragm cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 4.01937
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 3.32637
CD2AP CD2-associated protein 2.81241
KIRREL kin of IRRE like (Drosophila) 2.48726
ACTN4 actinin, alpha 4 1.68665
SYNPO synaptopodin 1.61295
TRPC6 transient receptor potential cation channel, subfamily C, member 6 1.57245
TJP1 tight junction protein 1 1.4041
KIRREL2 kin of IRRE like 2 (Drosophila) 1.33142
LMX1B LIM homeobox transcription factor 1, beta 1.29639
KIRREL3 kin of IRRE like 3 (Drosophila) 1.2905
DDN dendrin 1.27292
WT1 Wilms tumor 1 1.17568
IGSF5 immunoglobulin superfamily, member 5 1.11582
SOX12 SRY (sex determining region Y)-box 12 1.05892
ALB albumin 1.03529
WTIP Wilms tumor 1 interacting protein 1.02779
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 0.998577
FYN FYN proto-oncogene, Src family tyrosine kinase 0.899962
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.880094
SH2D4A SH2 domain containing 4A 0.850206
LRP2 low density lipoprotein receptor-related protein 2 0.835056
PLCE1 phospholipase C, epsilon 1 0.726599
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 0.711908
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 0.698223
ACE angiotensin I converting enzyme 0.693393
STOM stomatin 0.680284
PODXL podocalyxin-like 0.676803
EFNB1 ephrin-B1 0.63715
PLXNA1 plexin A1 0.60655
RARA retinoic acid receptor, alpha 0.591812
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.572578
FAT1 FAT atypical cadherin 1 0.551012
SH2D5 SH2 domain containing 5 0.524294
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.512455
KCTD7 potassium channel tetramerization domain containing 7 0.500664
ARL4C ADP-ribosylation factor-like 4C 0.486096
VEGFA vascular endothelial growth factor A 0.485693
SDK1 sidekick cell adhesion molecule 1 0.485289
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.478843
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.477233
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.476027
CMIP c-Maf inducing protein 0.473215
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.464798
IQGAP1 IQ motif containing GTPase activating protein 1 0.446069
VASH1 vasohibin 1 0.417294
ILK integrin-linked kinase 0.404415
CLIC5 chloride intracellular channel 5 0.402081
MYH9 myosin, heavy chain 9, non-muscle 0.400139
SV2B synaptic vesicle glycoprotein 2B 0.384665
TCF21 transcription factor 21 0.383895
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.373132
ZHX1 zinc fingers and homeoboxes 1 0.367388
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.367006
CTTN cortactin 0.342285
VANGL2 VANGL planar cell polarity protein 2 0.340773
ABRA actin binding Rho activating protein 0.340017
RBBP7 retinoblastoma binding protein 7 0.320077
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.31783
PARD6A par-6 family cell polarity regulator alpha 0.316708
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.308494
CTSL cathepsin L 0.304771
EZR ezrin 0.298826
AMOTL1 angiomotin like 1 0.298084
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.292897
PLA2R1 phospholipase A2 receptor 1, 180kDa 0.278877
COX6C cytochrome c oxidase subunit VIc 0.273367
STS steroid sulfatase (microsomal), isozyme S 0.273
PLXNA2 plexin A2 0.272633
CXADR coxsackie virus and adenovirus receptor 0.271167
PICK1 protein interacting with PRKCA 1 0.266042
S100A4 S100 calcium binding protein A4 0.264581
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.26166
EHD3 EH-domain containing 3 0.25438
MYO1E myosin IE 0.247854
TNS2 tensin 2 0.246046
MYO1C myosin IC 0.241356
XPR1 xenotropic and polytropic retrovirus receptor 1 0.239557
THY1 Thy-1 cell surface antigen 0.238119
COL4A5 collagen, type IV, alpha 5 0.236683
TGFB1 transforming growth factor, beta 1 0.234174
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.232029
CFL1 cofilin 1 (non-muscle) 0.232029
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.219969
SRA1 steroid receptor RNA activator 1 0.217511
CLDN6 claudin 6 0.214366
SOX11 SRY (sex determining region Y)-box 11 0.211933
CTNND1 catenin (cadherin-associated protein), delta 1 0.207794
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.202346
LRRC7 leucine rich repeat containing 7 0.200328
INF2 inverted formin, FH2 and WH2 domain containing 0.188905
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.181823
IFITM2 interferon induced transmembrane protein 2 0.179752
SOX4 SRY (sex determining region Y)-box 4 0.170114
MAF1 MAF1 homolog (S. cerevisiae) 0.160053
LAMB2 laminin, beta 2 (laminin S) 0.159268
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 0.158882
PHB prohibitin 0.158502