smad1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description SMAD family member 1|The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4086)
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Genes

42 genes co-occuring with the biological term smad1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACVR1 activin A receptor, type I
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMP6 bone morphogenetic protein 6
BMPR1A bone morphogenetic protein receptor, type IA
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CAV1 caveolin 1, caveolae protein, 22kDa
CSMD1 CUB and Sushi multiple domains 1
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DVL1 dishevelled segment polarity protein 1
ENG endoglin
FOXP3 forkhead box P3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
LEP leptin
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MIR205 microRNA 205
MIR30B microRNA 30b
MSX2 msh homeobox 2
NOTCH1 notch 1
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD7 SMAD family member 7
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR3 transforming growth factor, beta receptor III
UBE2I ubiquitin-conjugating enzyme E2I
USP15 ubiquitin specific peptidase 15
WNT3A wingless-type MMTV integration site family, member 3A