smad2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description SMAD family member 2|The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 4087)
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Genes

89 genes co-occuring with the biological term smad2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACVR1C activin A receptor, type IC
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
ARAF A-Raf proto-oncogene, serine/threonine kinase
BMP6 bone morphogenetic protein 6
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHUK conserved helix-loop-helix ubiquitous kinase
COL1A1 collagen, type I, alpha 1
CSMD1 CUB and Sushi multiple domains 1
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTGF connective tissue growth factor
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DCN decorin
ENG endoglin
ERBB2IP erbb2 interacting protein
FSHB follicle stimulating hormone, beta polypeptide
HAS1 hyaluronan synthase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HSPA4 heat shock 70kDa protein 4
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
LEMD3 LEM domain containing 3
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MIR146A microRNA 146a
MIR148A microRNA 148a
MIR155 microRNA 155
MIR18A microRNA 18a
MIR18B microRNA 18b
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA6 nuclear receptor coactivator 6
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFYC nuclear transcription factor Y, gamma
NKX2-1 NK2 homeobox 1
NODAL nodal growth differentiation factor
NUP153 nucleoporin 153kDa
NUP214 nucleoporin 214kDa
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PIAS1 protein inhibitor of activated STAT, 1
PML promyelocytic leukemia
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTEN phosphatase and tensin homolog
RLN2 relaxin 2
S100A4 S100 calcium binding protein A4
SDC2 syndecan 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SP1 Sp1 transcription factor
TDGF1 teratocarcinoma-derived growth factor 1
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TP63 tumor protein p63
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
VEGFA vascular endothelial growth factor A
VIM vimentin
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZFYVE16 zinc finger, FYVE domain containing 16
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF580 zinc finger protein 580