smad3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description SMAD family member 3|The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009] (NCBI Entrez Gene Database, 4088)
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Genes

139 genes co-occuring with the biological term smad3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACHE acetylcholinesterase (Yt blood group)
ACVR1C activin A receptor, type IC
ACVRL1 activin A receptor type II-like 1
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
AR androgen receptor
ARID1A AT rich interactive domain 1A (SWI-like)
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
CCL2 chemokine (C-C motif) ligand 2
CCNE1 cyclin E1
CCR2 chemokine (C-C motif) receptor 2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
COL1A2 collagen, type I, alpha 2
CREBBP CREB binding protein
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSMD1 CUB and Sushi multiple domains 1
CSNK1G2 casein kinase 1, gamma 2
CTGF connective tissue growth factor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
EPAS1 endothelial PAS domain protein 1
ERBB2IP erbb2 interacting protein
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FMNL2 formin-like 2
FOXL2 forkhead box L2
FOXM1 forkhead box M1
FOXO3 forkhead box O3
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GATA4 GATA binding protein 4
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GREM1 gremlin 1, DAN family BMP antagonist
GSK3B glycogen synthase kinase 3 beta
HAS1 hyaluronan synthase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ICOS inducible T-cell co-stimulator
IFNG interferon, gamma
IL15 interleukin 15
IL1B interleukin 1, beta
IL21 interleukin 21
IL6 interleukin 6
INHBA inhibin, beta A
JUN jun proto-oncogene
KDM5C lysine (K)-specific demethylase 5C
KDM6B lysine (K)-specific demethylase 6B
LEMD3 LEM domain containing 3
LTBP1 latent transforming growth factor beta binding protein 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MIR140 microRNA 140
MIR145 microRNA 145
MIR146A microRNA 146a
MIR193B microRNA 193b
MIR29C microRNA 29c
MIR34B microRNA 34b
MIR489 microRNA 489
MIR92B microRNA 92b
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA6 nuclear receptor coactivator 6
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NET1 neuroepithelial cell transforming 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFE2L2 nuclear factor, erythroid 2-like 2
NFYC nuclear transcription factor Y, gamma
NKX2-1 NK2 homeobox 1
NODAL nodal growth differentiation factor
NOTCH1 notch 1
NOTCH4 notch 4
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
NUP214 nucleoporin 214kDa
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PARP1 poly (ADP-ribose) polymerase 1
PIAS3 protein inhibitor of activated STAT, 3
PIAS4 protein inhibitor of activated STAT, 4
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
PPARG peroxisome proliferator-activated receptor gamma
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTTG1 pituitary tumor-transforming 1
RAN RAN, member RAS oncogene family
RGCC regulator of cell cycle
RHOA ras homolog family member A
S100A4 S100 calcium binding protein A4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD7 SMAD family member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNAI1 snail family zinc finger 1
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBR1 transforming growth factor, beta receptor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TRIM62 tripartite motif containing 62
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TSC22D1 TSC22 domain family, member 1
TTF1 transcription termination factor, RNA polymerase I
TWIST1 twist family bHLH transcription factor 1
TXN thioredoxin
VEGFA vascular endothelial growth factor A
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WWOX WW domain containing oxidoreductase
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XPO4 exportin 4
YBX1 Y box binding protein 1
ZFYVE16 zinc finger, FYVE domain containing 16
ZFYVE9 zinc finger, FYVE domain containing 9