smad4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description SMAD family member 4|This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 4089)
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Genes

108 genes co-occuring with the biological term smad4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGR2 anterior gradient 2
AR androgen receptor
BAMBI BMP and activin membrane-bound inhibitor
BBC3 BCL2 binding component 3
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMPR1A bone morphogenetic protein receptor, type IA
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CAV1 caveolin 1, caveolae protein, 22kDa
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CLTC clathrin, heavy chain (Hc)
COL1A1 collagen, type I, alpha 1
CRYAB crystallin, alpha B
CSMD1 CUB and Sushi multiple domains 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DACH1 dachshund family transcription factor 1
DAXX death-domain associated protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFNA2 ephrin-A2
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
FHL2 four and a half LIM domains 2
FOXM1 forkhead box M1
FSCN1 fascin actin-bundling protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GATA4 GATA binding protein 4
HOXA9 homeobox A9
HRAS Harvey rat sarcoma viral oncogene homolog
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL6 interleukin 6
IPO7 importin 7
IPO8 importin 8
JUN jun proto-oncogene
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT23 keratin 23, type I
LAMA3 laminin, alpha 3
LEF1 lymphoid enhancer-binding factor 1
LEMD3 LEM domain containing 3
MIR1260B microRNA 1260b
MIR130A microRNA 130a
MIR146A microRNA 146a
MIR182 microRNA 182
MIR183 microRNA 183
MIR205 microRNA 205
MIR20A microRNA 20a
MIR224 microRNA 224
MIR376C microRNA 376c
MIR483 microRNA 483
MIR494 microRNA 494
MIR888 microRNA 888
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MST1R macrophage stimulating 1 receptor
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NDRG1 N-myc downstream regulated 1
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLK nemo-like kinase
NUP214 nucleoporin 214kDa
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARP1 poly (ADP-ribose) polymerase 1
PLAU plasminogen activator, urokinase
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOT1 ras homolog family member T1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A8 S100 calcium binding protein A8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SP1 Sp1 transcription factor
STK11 serine/threonine kinase 11
SUMO1 small ubiquitin-like modifier 1
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THRA thyroid hormone receptor, alpha
TIAF1 TGFB1-induced anti-apoptotic factor 1
TNF tumor necrosis factor
TOB1 transducer of ERBB2, 1
TP53 tumor protein p53
TRIM33 tripartite motif containing 33
TSC22D1 TSC22 domain family, member 1
TTF1 transcription termination factor, RNA polymerase I
UBE2I ubiquitin-conjugating enzyme E2I
USP9X ubiquitin specific peptidase 9, X-linked
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WNT1 wingless-type MMTV integration site family, member 1
WWOX WW domain containing oxidoreductase
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YY1 YY1 transcription factor
ZFYVE16 zinc finger, FYVE domain containing 16