smad7 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description SMAD family member 7|The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 4092)
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Genes

78 genes co-occuring with the biological term smad7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACVR1 activin A receptor, type I
AKT1 v-akt murine thymoma viral oncogene homolog 1
APP amyloid beta (A4) precursor protein
ATM ATM serine/threonine kinase
AXIN1 axin 1
BAMBI BMP and activin membrane-bound inhibitor
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL1A1 collagen, type I, alpha 1
COPS5 COP9 signalosome subunit 5
CTGF connective tissue growth factor
EGF epidermal growth factor
ETV1 ets variant 1
FST follistatin
GPRASP1 G protein-coupled receptor associated sorting protein 1
GREM1 gremlin 1, DAN family BMP antagonist
HAMP hepcidin antimicrobial peptide
HNF1B HNF1 homeobox B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IHG1 iris hypoplasia with glaucoma 1
IL1B interleukin 1, beta
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
LTBP1 latent transforming growth factor beta binding protein 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MIR17 microRNA 17
MIR181C microRNA 181c
MIR21 microRNA 21
MIR216A microRNA 216a
MIR25 microRNA 25
MIR520G microRNA 520g
MMP2 matrix metallopeptidase 2
MSTN myostatin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNF111 ring finger protein 111
RUNX3 runt-related transcription factor 3
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFB1 transforming growth factor, beta 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
TNF tumor necrosis factor
TOLLIP toll interacting protein
TP53 tumor protein p53
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XPO1 exportin 1
YY1 YY1 transcription factor
ZEB1 zinc finger E-box binding homeobox 1