small GTPase-mediated signal transduction Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
External Link http://amigo.geneontology.org/amigo/term/GO:0007264
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Genes

189 genes participating in the small GTPase-mediated signal transduction biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABI2 abl-interactor 2
ABR active BCR-related
ADGRG1 adhesion G protein-coupled receptor G1
ADRA2A adrenoceptor alpha 2A
AGTR1 angiotensin II receptor, type 1
AIF1 allograft inflammatory factor 1
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP1 Rho GTPase activating protein 1
ARHGAP12 Rho GTPase activating protein 12
ARHGAP15 Rho GTPase activating protein 15
ARHGAP18 Rho GTPase activating protein 18
ARHGAP27 Rho GTPase activating protein 27
ARHGAP29 Rho GTPase activating protein 29
ARHGAP30 Rho GTPase activating protein 30
ARHGAP31 Rho GTPase activating protein 31
ARHGAP32 Rho GTPase activating protein 32
ARHGAP33 Rho GTPase activating protein 33
ARHGAP35 Rho GTPase activating protein 35
ARHGAP4 Rho GTPase activating protein 4
ARHGAP5 Rho GTPase activating protein 5
ARHGAP6 Rho GTPase activating protein 6
ARHGAP8 Rho GTPase activating protein 8
ARHGAP9 Rho GTPase activating protein 9
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARL3 ADP-ribosylation factor-like 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCR breakpoint cluster region
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
C15ORF62 chromosome 15 open reading frame 62
C6ORF89 chromosome 6 open reading frame 89
CCDC88A coiled-coil domain containing 88A
CCDC88C coiled-coil domain containing 88C
CCNA2 cyclin A2
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5
CDH13 cadherin 13
CDK2 cyclin-dependent kinase 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CDPF1 cysteine-rich, DPF motif domain containing 1
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL1A2 collagen, type I, alpha 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYFIP1 cytoplasmic FMR1 interacting protein 1
DBNL drebrin-like
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DOCK7 dedicator of cytokinesis 7
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
ELMO1 engulfment and cell motility 1
EPS8 epidermal growth factor receptor pathway substrate 8
EPS8L1 EPS8-like 1
EPS8L2 EPS8-like 2
EPS8L3 EPS8-like 3
ERAS ES cell expressed Ras
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FGF13 fibroblast growth factor 13
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GARRE1 granule associated Rac and RHOG effector 1
GDI1 GDP dissociation inhibitor 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1 insulin-like growth factor 1 (somatomedin C)
KRIT1 KRIT1, ankyrin repeat containing
KSR1 kinase suppressor of ras 1
KSR2 kinase suppressor of ras 2
LIMK1 LIM domain kinase 1
LRRK2 leucine-rich repeat kinase 2
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MRAS muscle RAS oncogene homolog
MYO9B myosin IXB
NCKAP1 NCK-associated protein 1
NCOA3 nuclear receptor coactivator 3
NF1 neurofibromin 1
NGFR nerve growth factor receptor
NKIRAS1 NFKB inhibitor interacting Ras-like 1
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTN1 netrin 1
NUCB1 nucleobindin 1
NUCB2 nucleobindin 2
PARK7 parkinson protein 7
PDPN podoplanin
PHACTR4 phosphatase and actin regulator 4
PLCD4 phospholipase C, delta 4
PLCE1 phospholipase C, epsilon 1
PLD2 phospholipase D2
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7
PLK2 polo-like kinase 2
PRKCSH protein kinase C substrate 80K-H
RAB18 RAB18, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB6C RAB6C, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic)
RALGDS ral guanine nucleotide dissociation stimulator
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGEF1A RasGEF domain family, member 1A
RASGEF1B RasGEF domain family, member 1B
RASGEF1C RasGEF domain family, member 1C
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASGRP4 RAS guanyl releasing protein 4
RASL10A RAS-like, family 10, member A
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
REPS1 RALBP1 associated Eps domain containing 1
RERG RAS-like, estrogen-regulated, growth inhibitor
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGL3 ral guanine nucleotide dissociation stimulator-like 3
RGL4 ral guanine nucleotide dissociation stimulator-like 4
RGS19 regulator of G-protein signaling 19
RHEB Ras homolog enriched in brain
RHEBL1 Ras homolog enriched in brain like 1
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOD ras homolog family member D
RHOG ras homolog family member G
RIN2 Ras and Rab interactor 2
RIPOR1 RHO family interacting cell polarization regulator 1
RIT2 Ras-like without CAAX 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
ROPN1B rhophilin associated tail protein 1B
RRAD Ras-related associated with diabetes
RRAGC Ras-related GTP binding C
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RTKN rhotekin
RUNDC3A RUN domain containing 3A
SGSM3 small G protein signaling modulator 3
SHTN1 shootin 1
SIAH2 siah E3 ubiquitin protein ligase 2
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPNS1 spinster homolog 1 (Drosophila)
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TNK2 tyrosine kinase, non-receptor, 2
TP53 tumor protein p53
USP50 ubiquitin specific peptidase 50
USP8 ubiquitin specific peptidase 8
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1