small cell lung cancer Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)|A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis.|A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis. (NCI05) (Experimental Factor Ontology, EFO_0000702)
External Link http://www.genome.jp/kegg/pathway/hsa/hsa05222.html
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Genes

85 proteins participating in the small cell lung cancer pathway from the KEGG Pathways dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
APAF1 apoptotic peptidase activating factor 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CCNE1 cyclin E1
CCNE2 cyclin E2
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHUK conserved helix-loop-helix ubiquitous kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A4 collagen, type IV, alpha 4
COL4A6 collagen, type IV, alpha 6
CYCS cytochrome c, somatic
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
FHIT fragile histidine triad
FN1 fibronectin 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
LAMA1 laminin, alpha 1
LAMA2 laminin, alpha 2
LAMA3 laminin, alpha 3
LAMA4 laminin, alpha 4
LAMA5 laminin, alpha 5
LAMB1 laminin, beta 1
LAMB2 laminin, beta 2 (laminin S)
LAMB3 laminin, beta 3
LAMB4 laminin, beta 4
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMC2 laminin, gamma 2
LAMC3 laminin, gamma 3
MAX MYC associated factor X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
PIAS1 protein inhibitor of activated STAT, 1
PIAS2 protein inhibitor of activated STAT, 2
PIAS3 protein inhibitor of activated STAT, 3
PIAS4 protein inhibitor of activated STAT, 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
RARB retinoic acid receptor, beta
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
RXRG retinoid X receptor, gamma
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF4 TNF receptor-associated factor 4
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
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