small pancreatic islets Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas (Mammalian Phenotype Ontology, MP_0009172)
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40 gene mutations causing the small pancreatic islets phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALX3 ALX homeobox 3
AQP7 aquaporin 7
BAD BCL2-associated agonist of cell death
BGLAP bone gamma-carboxyglutamate (gla) protein
CDK4 cyclin-dependent kinase 4
CES1 carboxylesterase 1
CLOCK clock circadian regulator
COL1A1 collagen, type I, alpha 1
DACH1 dachshund family transcription factor 1
E2F1 E2F transcription factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
GCK glucokinase (hexokinase 4)
GDF11 growth differentiation factor 11
GHR growth hormone receptor
GLIS3 GLIS family zinc finger 3
HHIP hedgehog interacting protein
HIPK3 homeodomain interacting protein kinase 3
HMGA1 high mobility group AT-hook 1
INS insulin
INSL5 insulin-like 5
INSM1 insulinoma-associated 1
IRS2 insulin receptor substrate 2
KL klotho
LEP leptin
MGMT O-6-methylguanine-DNA methyltransferase
MNX1 motor neuron and pancreas homeobox 1
MPG N-methylpurine-DNA glycosylase
MYD88 myeloid differentiation primary response 88
NCOA5 nuclear receptor coactivator 5
NKX2-2 NK2 homeobox 2
NKX6-1 NK6 homeobox 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PDX1 pancreatic and duodenal homeobox 1
PRLR prolactin receptor
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBM4 RNA binding motif protein 4
RBM4B RNA binding motif protein 4B
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
THRA thyroid hormone receptor, alpha
TLR2 toll-like receptor 2