smooth muscle contraction Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. (Gene Ontology, GO_0006939)
External Link http://amigo.geneontology.org/amigo/term/GO:0006939
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Genes

15 genes participating in the smooth muscle contraction biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ADRA1A adrenoceptor alpha 1A
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BDKRB2 bradykinin receptor B2
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
EDNRA endothelin receptor type A
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NMUR1 neuromedin U receptor 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SMTN smoothelin
TPCN2 two pore segment channel 2