smoothened signaling pathway Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. (Gene Ontology, GO_0007224)
External Link http://amigo.geneontology.org/amigo/term/GO:0007224
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Genes

36 genes participating in the smoothened signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ARL13B ADP-ribosylation factor-like 13B
B9D1 B9 protein domain 1
CC2D2A coiled-coil and C2 domain containing 2A
DHH desert hedgehog
DISP1 dispatched homolog 1 (Drosophila)
DISP2 dispatched homolog 2 (Drosophila)
DISP3 dispatched RND transporter family member 3
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EVC2 Ellis van Creveld syndrome 2
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
GPC2 glypican 2
HES5 hes family bHLH transcription factor 5
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
HSPB11 heat shock protein family B (small), member 11
IFT27 intraflagellar transport 27
IHH indian hedgehog
KIAA0586 KIAA0586
MAP3K10 mitogen-activated protein kinase kinase kinase 10
PKD2L1 polycystic kidney disease 2-like 1
PTCH1 patched 1
PTCHD1 patched domain containing 1
SEPTIN2 septin 2
SHH sonic hedgehog
SMOX spermine oxidase
STIL SCL/TAL1 interrupting locus
STK36 serine/threonine kinase 36
TCTN2 tectonic family member 2
TCTN3 tectonic family member 3
TMEM17 transmembrane protein 17
TMEM231 transmembrane protein 231
TTBK2 tau tubulin kinase 2
TTC26 tetratricopeptide repeat domain 26
ULK3 unc-51 like kinase 3